Nzymes.com: Same Snake Oil, Different Day

Knowing that I have an interest in investigating the evidence behind claims for veterinary healthcare products, clients and colleagues sometimes pass along materials concerning veterinary supplements, herbal remedies, and other similar products and ask my opinion. Since there are hundreds, if not thousands of products marketed to pet owners to preserve or restore their pets’ health, I can only look into a few. However, the more of these I investigate, the more clearly I see the patterns of disregard for science and manipulation of the consumer that they have in common.

The latest in this category is a collection of products from a company called Nzymes.com. The website and pamphlet for this company exhibits nearly all of the warning signs of quackery. The company systematically tries to frighten the consumer by suggesting that pets cannot be healthy without their product and that the food and healthcare they are currently getting is inadequate.

Give Your Pet a Fighting Chance

If you are feeding your pet one of today’s popular processed pet foods, then chances are, your pet’s body is depleted of the primary enzyme precursors nature provides abundantly in all living foods.

The fact that we continue to feed our pets such enzyme-less food over an entire lifetime may contribute to the growing list of animal health problems we witness today including; osteoarthritis, inflammation, joint pain, hip dysplasia, pano, OCD, HOD, shedding, hair loss, dry skin, itchy skin, digestive disorders, gastritis, pet food allergies, epilepsy, fatigue, hot spots, and many other stress related symptoms contributed to by a weakened immune system.

The whole “living enzyme” argument is complete nonsense, and there is no evidence for the suggestion that commercial diets are nutritionally deficient or responsible for this long, redundant list of random symptoms and disorders. Some of these problems may be related to nutrition, but that has nothing to do with the claim made here, which is baseless.

But the pseudoscientific nonsense doesn’t stop there. The web site also blames pet food, vaccines, and medications for a variety of ailments, again without paying any attention to the real, and complicated, risks and benefits of these interventions. Classic quack nonsense like claims about the Pottenger cat “study,” about boosting the immune system, about mysterious “toxins” as a cause of unrelated diseases,  and about Candida yeast infections as a common cause of many health problems are all over the company web site.

So, what are they selling with all this fear? Apparently, miraculous panaceas with uncounted benefits and absolutely no risks! Since they aren’t allowed to claim they can actually prevent or treat any disease without having evidence to support it (though they effectively do, despite the Quack Miranda Warning here and there), they promise to “support”

Healthy Joint function, Healthy Muscle Function, Healthy Skin and Coat, Healthy Nervous System, Healthy Immune System, Healthy Circulatory System, Healthy Endocrine System, Healthy Lymphatic System, Healthy Digestive System, Healthy Urinary Function, Healthy reproductive Function, Healthy respiratory System, Healthy organ Function, General Overall Wellbeing

I like how they throw in “Healthy Organ Function” and “General Overall Wellbeing” just to cover any possible body part they might not have thought of. So if you’re afraid the imaginary causes of illness they mention have caused your pets’ problem, or might cause something bad someday, you can take comfort from knowing they this product can treat or prevent absolutely everything (except when it can’t, in which case it’s because of the food, the water, the medications, or anything else except the lack of benefit of their product). 

What, exactly, are the miracle elixirs offered by Nzymes.com?

Ox-E drops
This consists of 5% sodium chlorite, a chemical related to bleach. Properly diluted, this chemical is a safe disinfectant, killing infectious organisms through oxidation. With a pH of 13, if not diluted the chemical can cause burns, especially to the eyes and mucous membranes. Accidental overdose can be fatal.

The company advertises this as helping in “the removal of potentially dangerous free radicals and toxins,” and claims that is boosts the immune system, supports digestion, and enhances “performance.”  Impressive claims for a potentially toxic disinfectant that is actually an oxidant rather than an anti-oxidant.

As the accompanying quack Miranda warning attests, and a simple literature search confirms, there is absolutely no evidence for any of these claims. Plenty of testimonials are offered, of course, which is always the evidence of choice for products that are based on pseudoscience and have never been tested in any reliable way.

Antioxidant Treats
The antioxidant hype is a common marketing ploy for supplements because it’s vague, and there is enough suggestive preclinical research to suggest the general idea is plausible. Unfortunately, there are few clinical trials which show significant real benefits from particular anti-oxidants in particular conditions, and the evidence is growing that some such agents, such as Vitamin E, can actually increase the risk of disease.

The specific ingredients include Vitamin A, Vitamin C, Vitamin E, and a proprietary freeze-dried sprouted soybean meal claimed to contain:

The amount of the vitamins in the supplement are far in excess of what is recommended to prevent deficiency.

Vitamin A- 1000IU (recommended daily dose 50IU/kg, safe upper limit 2,099IU)
Vitamin C- 30mg (recommended daily dose 0, dogs and cats make their own)
Vitamin E- 5IU (recommended daily dose 1mg/kg)

These amounts are probably not high enough to cause harm, but given that most pets are fed diets already supplemented with more than enough of each, the amounts in this product are unnecessary as nutrients. The use of excess amounts of these vitamins as medicines to prevent or treat disease, is not proven, and has often turned out to do more harm than good when tried in humans.

As for the sprouted soybean meal, there is no scientific evidence to suggest health benefits from this either. The company sites a variety of epidemiological studies in humans indicating an association between eating tofu or other soybean food products and lower cholesterol levels, rates of some cancers, and a few other health problems. (They do not, of course, refer to any of the research in humans showing lack of benefit or potential risks from soy supplement products). All of this, unfortunately, is entirely irrelevant to whether or not this particular soy-based product has any benefits for dogs and cats.

The amino acids, vitamins, and minerals listed are all provided in adequate amounts in good quality commercial pet foods. The enzymes are of no benefit, particularly when taken orally since they themselves are destroyed by normal digestion. And none of the phytochemicals have yet been demonstrated to have any health benefits in dogs and cats. So while it is unlikely to be harmful, to is an expensive way to get a few nutrients your pet probably already has enough of and some chemicals that may or may not have any health effects, positive or negative. 

Black Leaf Tincture
This is an herbal product containing black walnut extract, olive leaf extract, and cayenne in 75% alcohol(!). The usual vague and unscientific claims are offered about supporting the immune system, the circulatory system, the digestive system, and so on.

Black Walnut- There is insufficient evidence to support any of the claimed health benefits despite traditional use for a wide range of unrelated problems. There is some concern about possible toxicity, from the walnut itself and from possible fungal contaminates.

Olive Leaf- The evidence in humans suggests some possible beneficial effects on blood pressure and cholesterol levels, but it is weak and not conclusive. There is no eveidence on the possible effects in dogs and cats.

Cayenne- There is a fairly large amount of preclinical research suggesting possible benefits in humans, but little in the way of clinical trial evidence, and nothing in dogs and cats. 

Probiotic
I’ve written extensively about probiotics, and this is an area in which I think some real benefits are possible. Unfortunately, we have yet to develop an adequate understanding of the normal gut ecology to be able to influence it in significant ways, and the evidence for real clinical benefits from specific products varies from weak to non-existent. Nzymes.com does nothing to change this. Their product contains a variety of typical probiotic bugs, and there have been no clinical trials to show that the specific combination has any value. The product was tested, however, in a study looking at quality and label accuracy for veterinary probiotics. It was found to contain only 2.7% of the number of bacteria claimed on the label, suggesting even the ingredient claims made for this product may be questionable, much less the claims of health benefits. 

“A Veterinary Study”
The company does claim to have one rather large veterinary clinical study from 1989 showing that dogs with musculoskeletal pain benefit from its sprouted soybean product. The study was never apparently published, and the information provided on the web site does not make it possible to evaluate it extensively. Six unnamed veterinarians apparently diagnosed dogs with “musculoskeletal inflammation” based on their own exams and the opinions of owners. They gave the supplement to 387 dogs, and 340 of them were reported as improved in one of more of these measures: energy, alertness, stamina, appetite, and accelerated healing. Most cases improved within the first week.

This is almost a cartoon caricature of what a scientific study shouldn’t be. No randomization, no placebo control group, no standardized diagnostic evaluation, no objective diagnostic evaluation (all subjective), no clearly defined diagnosis, no blinding, no record of other conditions or treatments used, and no predetermined or even halfway consistent criteria for response. Any high school science class ought to be able to put together a better “study.” If this is the best the company has been able to do in over 20 years, there is absolutely no reason to believe they have any interest in the scientific validity of their marketing claims. 

Bottom Line
These products are being marketed with an impressive number of the myths and warning signs of snake oil and pseudoscience. The theories offered for why these remedies should help your pet range from complete nonsense to vague unproven hypotheses. There is no scientific evidence to indicate any specific benefit from any of these products for any particular condition in dogs and cats. All the testimonials in the world can’t prove any of the company’s claims to be true, nor can they guarantee that the products cannot hurt your pets. Just as there is little evidence regarding the claimed benefits of these products, there is little to demonstrate that they are safe.

 

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110 Responses to Nzymes.com: Same Snake Oil, Different Day

  1. Stefanie says:

    These products helped heal my dogs ailments when nothing else did. Products prescribed by her vet only worked for a week or two, but then her symptoms would flair up worse than ever. Scaby/smelly skin, red spots that very obviously bothered her, excessive shedding, bumps all over, just to name a few.
    I stand behind these products 100%. Your article, while articulate, does not take away from the fact that these products do work. You would be hard pressed to find negative feedback from anyone using them on their pets for short term or long term basis.

  2. skeptvet says:

    Unfortunately, the truth is not a popularity contest. After all, bloodletting was also wildly popular for thousands of years, and it actively killed people without helping them at all. Hee are just a few of the reasons why testimonials mislead us:

    Why We’re Often Wrong
    Testimonials Lie
    The Role of Anecdotes in Science-Based Medicine
    Why We Need Science: “I saw it with my own eyes” Is Not Enough
    Don’t Believe your Eyes (or Your Brain)

  3. Blake says:

    Thanks skeptvet for your candid blog about truth and facts vs claims and testimonials. As a pet owner and dog care business owner I am always asked questions about health and nutrition and supplements and food recommendations. My question is this: your statements are true about how nzymes.com presents itself, is there a company or product that does meet tested standards that has proven results?

  4. skeptvet says:

    It depends on what you mean. There are some supplements that have moderate to strong evidence for benefit (e.g. fish oils for allergic skin disease and arthritis), so companies selling those that stick to claims supported by good evidence are certainly meeting the basic standard of truthfulness in their advertising. Similarly, some products have limited evidence or are based only on a plausible but unproven theory. Companies that sell such products only by making limited and appropriate claims are behaving responsibly even if the evidence hasn’t yet shown with certainty their products work. The makers of Ocu-Glo, for example, made only limited, appropriate claims for their product initially, and they only expanded those claims when additional research evidence was available. That is an example of how such companies could and should behave.

    There is, of course, no panacea that cures many different conditions with zero risks, so nothing is going to be able to meet the standards of evidence necessary to support the kind of wide-ranging and dramatic claims all too often made for products like Nzymes. But there are companies that do a better and worse job of sticking to reasonable, evidence-based claims about their products.

  5. Angie says:

    One day I noticed my 2 year old bulldog was straining to pee but not able to empty his bladder. After an emergency consult, surgery and more consultations with even more vets, it was decided that my dog was probably suffering from an intolerance/allergy to something in his daily diet. I was told that the problem, in their experience, was most likely to have something to do with the meat proteins in his dog food. I was provided with a dog food brand that was “conveniently” being sold through the vet office.

    After the first day of the new food my dog developed horrible diarrhea. The vet reassured me that this was simply a matter of getting my dog use to the new food. Within 3 days of being on the “healthy” food, my dog became so lethargic he wouldn’t get off his mat. He had no interest in his toys, going out for walks, or even treats. Within a few days his skin became itchy/flaky and he seemed to be shedding a lot. Eventually he developed open lesions between his toes and his eyes were crusting shut, all in less than 10 days.

    When I told the vet that I would be discontinuing the prescribed dog food she angrily told me to choose between a dog that was simply uncomfortable or one that would constantly be facing life threatening health issues. Instead, I chose to find a new vet!

    Angry and frightened I was determined to do what I could to save my dog. Having seen first hand how radically diet could impact the health of my beloved pet, I made a few inquiries into the education of vets on this topic. I was probably very naive to expect nutrition to be something that veterinary medicine would address. After all, even most doctors with human patients know very little about dietary medicine. I have come to believe that what vets know about animal nutrition is basically whatever the pet food industry tells them.

    Looking for information on dog nutrition via the internet, I found the NZyme site and what I read there made sense to me. The switch in my dogs food did help with his lethargy but it wasn’t until I received and started using the NZyme products that his health really started to turn around. My new vet was amazed at the difference and now, 8 years later, I still swear by the product and will continue to recommend it to anyone who has an interest.

  6. skeptvet says:

    It can’t be said enough, this sort of story simply doesn’t tell us if these kinds of products are safe or effective. I wihs it were that easy, but it’s not.

    Why We’re Often Wrong
    Testimonials Lie
    The Role of Anecdotes in Science-Based Medicine
    Why We Need Science: “I saw it with my own eyes” Is Not Enough
    Don’t Believe your Eyes (or Your Brain)

  7. Jules Desjarlais says:

    I will be buying one container of NZYMES Sprout granules for pets and horses. Actually it’s for my horse, which has been limping from either a swollen tendon a prognosis from one vet or a Navicular syndrome another prognosis from another vet. I’ve tried a few different products but nothing seems to help. In one month I will give my results to see if this is just snake oil or not.

  8. Christine Donofrio says:

    My Corgie has lost the use of her hind legs. I purchased Nzymes because they implied that instead of a doggie wheelchair that the Nzymes have helped dogs to recover from this disability. I bought Nzymes and used it but my dog is still a paraplegic. In fact she was able to move her legs slightly but now not at all.
    As a pet parent, I do hope for miracles but I realize that there are no answers to the
    condition my pet is experiencing except to put her down. I don’t have the courage
    to do that and so I search and search for something.

  9. skeptvet says:

    Whatever happens, it won’t tell us anything useful about the safety or effectiveness of this product. Anecdotes are both deeply unreliable and almost always positive, even for remedies that don’t work, because that’s the nature of human psychology.

    Why We’re Often Wrong
    Testimonials Lie
    The Role of Anecdotes in Science-Based Medicine
    Why We Need Science: “I saw it with my own eyes” Is Not Enough
    Don’t Believe your Eyes (or Your Brain)

  10. Pam says:

    My babygirl was plagued with allergies and dry skin and ear infections and she was smelly. I have been using these products for over a year and followed the advice on the website about bathing, etc. She is 90% healed. They worked for my dog when nothing the doctor suggested did. Thank you as I was going to put my dog down. Anyone going through what we did will try anything and I’m thankful we did.

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