Archive for the ‘Commentary on Other Blogs’ Category

Stem Cell Therapy– Still an Uncontrolled Experiment on our Pets

Wednesday, June 23rd, 2010

Dr. Steven Novella at Science-Based Medicine recently posted about a publication from the International Society for Stem Cell Research which cautions people seeking stem cell therapies that most such treatments are unproven and experimental. This is an especially compelling advisory coming, as it does, from an organization committed to the study of stem cell therapies, and so presumably positively biased in favor of these treatments, at least in principle. It shows an impressive degree of scientific integrity.

The portions of the document that are most telling are the general introduction and the discussion of the limitations of current evidence for stem cell treatments, as well as the discussion of the need for detailed informed consent prior to any use of such therapies, given that they are experimental. In the introduction, the organization states:

We have all heard about the extraordinary promise that stem cell research holds for the treatment of a wide range of diseases and conditions. However, there is a lot of work still needed to take this research and turn it into safe and effective treatments.

The International Society for Stem Cell Research (ISSCR) is very concerned that stem cell therapies are being sold around the world before they have been proven safe and effective.

Stem cell therapies are nearly all new and experimental. In these early stages, they may not work, and there may be downsides. Make sure you understand what to look out for before considering a stem cell therapy.

Remember, most medical discoveries are based on years of research performed at universities and companies. There is a long process that shows first in laboratory studies and then in clinical research that something is safe and will work. Like a new drug, stem cell therapies must be assessed and meet certain standards before receiving approval from national regulatory bodies to be used to treat people.

In answer to the question “For what diseases or conditions are stem cell treatments well established?” they write:

The range of diseases for which there are proven treatments based on stem cells is still extremely small. Disorders of the blood and immune system and acquired loss of bone marrow function can, in some cases, be treated effectively with blood stem cell transplantation.

Doctors have been transferring blood stem cells by bone marrow transplant for more than 50 years, and advanced techniques for collecting blood stem cells are now used clinically. Umbilical cord blood, like bone marrow, is often collected as a source of blood stem cells and is being used experimentally as an alternative to bone marrow in transplantation.

Other tissue-specific stem cells may also play a role in tissue transplants that have been performed for several years. For tissues and organs such as skin and cornea, stem cells contained in these tissues contribute to long-term regeneration.

Other stem cell treatments are still experimental. This means that it has not yet been shown that this treatment is safe or that it will work.

This is clearly all the more true in veterinary medicine, where the sources of stem cells are sometimes atypical (such as fat-derived autologous cells) and the amount of good quality clinical research on the safety and effectiveness of such treatments is close to nil. And yet, these therapies are being sold and used in clinical practice, quite likely without the kind of detailed informed consent, assiduous follow-up, or other controls for bias and risk that would be expected in a clinical trial.

Once again, this is an example of a plausible therapy rushed to market without adequate evidence of safety or benefit. Such therapies rarely live up to their initial promise, and they expose the public to unnecessary risk as well as false hope. They also expose the professions of scientific medicine to rightly criticism about the impact of profit motive on our behavior, and to less legitimate criticism about the dangers of conventional medicine (and you know what will be suggested as the alternative….). We have a responsibility to our patients, clients, and our profession to be cautious in utilizing unproven treatments and in making sure clients understand the uncertain risks of such procedures.

Dr. Walt’s Warning Signs of Quackery

Thursday, June 17th, 2010

I ran across a series of posts from a physician which I think do a thorough job of identifying warning signs of unscientific, irrational or outright quack medical treatments. They’re not organized in a particularly systematic way, but they cover a lot of important ground. Below are the specific headings grouped under the post in which they appear, with the details to be found on Dr. Walt’s page.

Warning Signs- Post One
1. Is the product or practice promoted as a “Major Breakthrough,” “Revolutionary,” “Magic,” or “Miraculous”?

2. Do the promotions try to simply elicit an emotional reaction rather than present clear information to help you make an informed decision about the product?

3. Is only anecdotal or testimonial evidence used to support claims of effectiveness?

4. Are claims made about scientific support without giving specific details?

5. Is the information about the therapy or product being provided by a professional lacking in the proper credentials?

Warning Signs- Post Two
6. Are technical words used without a clear definition?

7. Would a treatment require you to abandon any well-established scientific laws or principles?

8. Do proponents claim that a medical system is so flawless (“airtight”) that there is no need for further testing?

9. Is the treatment said to be effective for a wide variety of unrelated physiological problems?

10. Is the product a quick and easy fix for a complicated and frustrating condition?

Warning Signs- Post Three
11. Does the proponent of the therapy claim to be criticized unfairly?

12. When challenged, do defenders attack the critic instead of responding to the challenge?

13. Do proponents claim that research will prove their therapy is effective as soon as studies are conducted?

14. Is training to provide the therapy offered only at obscure private institutions instead of accredited professional schools?

15. Do proponents use expertise in other areas to lend weight to their medical claims?

Warning Signs- Post Four
16. Is a therapy encouraged simply because it’s been used for centuries by people in some remote place?

17. Do proponents use statements that are basically true but unrelated to the therapy?

18. Do proponents blame failed tests of effectiveness on skepticism or outright nonbelief of observers?

19. Do proponents claim it is too difficult for most to understand how a therapy works, or that only the “enlightened” can understand?

20. Does the proponent disguise the truth with vague and misleading statements?

Warning Signs- Post Five
21. Does the product you’re considering require advance payment?

22. Does the advertisement promise a “money-back guarantee”?

23. Is the therapy available only in other countries?

24. Are there conflicts of interest?

25. Is the term “natural” the main advantage of the remedy?

Holistic Vet Asks, “IF CAM doesn’t work, why is it allowed?”

Wednesday, June 16th, 2010

A certain “holistic” veterinarian about whom I’ve written before (here, here, here, and—well, you get the idea) has asked a couple of good questions on his own blog, though not surprisingly I don’t find his answers at all convincing. I’m interested in talking about these questions not so much as a response to the fellow himself, who is beyond even considering any weaknesses in his own philosophy or view of the world, but  because they are truly good questions, and they provide an opportunity to look at some key elements to the persistence of ineffective veterinary treatments despite their lack of efficacy.

The first question was, “If natural therapies don’t work, and I continue to market them to the public and use them in my practice, am I guilty of ripping off the public?” The short answer, is “Yes!” which is part of why I write this blog.

Of course, I have made it clear many times that I doubt most vets, or others, practicing ineffective nonsense therapies like homeopathy, energy medicine, and so on, are actually intentionally lying. I accept that most of them truly believe that what they do is helpful, for all the reasons we all make poor judgments and delude ourselves from time to time. I don’t fault them for their mistaken beliefs, only for their arrogance in refusing to consider the evidence against them.

Rather than offer any evidence for the effectiveness of his methods, the author instead asks a series of somewhat ridiculous rhetorical questions.

Why have I never been prosecuted and convicted of being a con artist?

So the failure of the local DA to prosecute him for fraud proves that what he does works? No, it simply proves that what he is doing is (probably; he rarely offers specifics) not illegal and that he likely really believes it works and so is deceiving his clients unintentionally.

But the issue of illegal claims made on behalf of herbs, nutritional supplements, medical devices, and other CAM interventions is a real one. The law does limit what providers of such products and services can claim. Claims of being able to prevent or treat specific disease conditions are subject to laws and regulations requiring such claims be demonstrated by legitimate scientific evidence. The FDA, Federal Trade Commission, and other state and federal agencies have complex and overlapping webs of jurisdiction over such claims. Unfortunately, these organizations are understaffed and underfunded, and they have neither the resources nor the political will to police individual practitioners or organization.

I once asked a representative of the FDA’s Center for Veterinary Medicine how to best go about reporting illegal claims about veterinary therapies. She sighed and indicated that apart from large companies selling compounded drugs on a large scale, or products that might conceivably be a risk to human health directly or through food production, the agency was unlikely to be able to investigate or respond to such claims. I have, in fact, filed a number of complaints about egregiously and clearly illegal marketing of unlicensed therapies to the FDA and the FTC, and I have never had so much as an automatic email in response.  There are many reasons, practical and political, why unproven therapies are not subject to control by law enforcement, but their underlying effectiveness is not one of these reasons.  

Why do my patients improve when conventional doctors can’t help them?

Of course, he assumes this is true and would like us to assume so along with him. Once again, he offers no evidence of it, and we have no reason to believe it is so since the sorts of alternative approaches he advocates range from the possible but unproven to the outright ridiculous and impossible.

In the absence of any scientific study, CAM providers can claim what they like about the results of their treatments without fear of contradiction, and they frequently do. I could certainly advertise that I save lives where alternative therapies have failed. In fact, I believe I do! But such claims are not themselves proof of anything. Rarely are there direct comparisons of the effectiveness of a CAM treatment versus a scientific treatment, since this is precisely the sort of evidence CAM providers do not seem to feel they need.

Why does the public continue to come to me, seeking the kind of care I can offer their pets that they can’t get elsewhere.

This is indeed a good question, though the implication that people seek his care proves it must work is no more reasonable than the argument that people play the lottery so they must be winning. There are many reasons why people seek alternative medical care:

1. Desperation-As I’ve discussed before, people facing an illness that cannot be effectively treated by scientific medicine will resort to anything that gives them hope or the promise of a better outcome. This is understandable, and no one can be faulted for wanting their beloved pets to be better. Unfortunately, unproven and bogus therapies offer only false hope and often come with the risk of making things worse.

2. Comfort- I don’t know this particular vet, but I do know that many CAM practitioners seem to meet the psychological needs of their clients better than many conventional doctors. A caring demeanor, asking detailed and lengthy (even if medically meaningless) questions about every aspect of the patient’s life, a non-traditional, non-clinical consultation environment, and many other factors can make the genuine caring a CAM doctor feels for their patients clear to the clients.

It is a shame that the traditional medical environment and the time pressure many vets work under, as well as the lack of effective training in communication, sometimes mask the equally genuine caring science-based vets feel for their patients. And, of course, science-based vets are limited in the comfort they can offer by their need to be honest with clients about the uncertainties and limitations of medicine, whereas believers in miracles and magic can freely claim nothing is ever beyond hope of a cure.

3. Philosophy-Many clients seek alternative medical providers because they themselves are believers in vitalistic philosophies or are suspicious of science and conventional medicine for personal or political reasons. I once saw a clients whose dog was in great pain from a bone tumor. the dog would not walk on the affected leg, and he cried piteously when I touched it. The owner had come to me out of desperation after none of the alternative therapies she had chosen to pursue first had made the disease go away. I had some therapies to offer, though not a cure, but she refused to consider amputation, radiation, or other such conventional treatments because she believed them to be unnatural and harmful rather than beneficial. What struck me the most about her beliefs, though, was that she refused to consider any pain medication for her dog and seemed surprised and offended when I offered it. She was having acupuncture done to the dog and using a homeopathic remedy, and despite the obvious pain the animal was in, she really believed these were working, and she certainly believed they were better than “toxic drugs”. People will ignore great even powerful and obvious information if it contradicts what they believe or wish to believe.

4. Control-CAM often involves changes in diet or lifestyle that the client is responsible for. This can give them a sense of control, of being able to actively do something to combat the illness their pet is facing. And CAM therapies are often given along with simple and intuitive explanations of the disease and the treatment, which is more appealing then the often complex, abstruse, and nuanced scientific descriptions of the pathophysiology of the disease and treatment. This too makes the client feel more in control and less bewildered by what is happening to their pet.

The second general question our holistic colleague asks is this:

If natural therapies don’t work, then why does the government (FDA, state licensing agencies, AVMA, etc.) allow me to use them in my practice? Why would the government, especially the FDA, knowingly not just allow but also support the use of natural therapies in the practice of medicine unless they are in on the “scam” too? Why does the FDA regulate homeopathic remedies (which the skeptics claim don’t work) just like they do conventional medicines if these homeopathic remedies are nothing more than “sugar pills?”

His answer?

The only conclusion someone can draw from this discussion is simply this: since the government allows doctors to use natural therapies, these therapies must work and have some value in the practice of medicine. Otherwise the government could easily make it illegal to use natural therapies and prevent doctors from using them. Punishment for using these unproven natural therapies would be swift and severe, such as the loss of the license to practice medicine and possibly even criminal penalties. Since this doesn’t happen, it must be that the government recognizes the value of using natural therapies in the practice of medicine.

Not even close. The reality is that government licensing and regulation is far more about politics than it is about science. As I’ve discussed before, homeopathic remedies were grandfathered in to the original laws establishing the FDA for purely political reasons. And technically, the FDA has ruled that this does not extend to the use of such remedies in animals, so they could prohibit them if they had the political will to do so, which clearly they do not.

Similarly, veterinarians are licensed at the state level, and their activities are limited by the provisions of state veterinary practice acts. These acts are written by legislators, who are clearly not scientists, and they rarely specify precisely what is or is not considered legitimate veterinary medicine. And, of course, we wouldn’t want them to since the science is far too complex and continually evolving to expect e could enshrine it in law. Specific interventions are sometimes legally prohibited, such as declawing of cats in some local jurisdictions, but this is uncommon and, again, driven by politics and public opinion, not sophisticated assessment of the scientific evidence for what constitutes effective or ineffective therapy.

And the professional organizations that represent veterinarians are reluctant to make strong statements about what is or is not legitimate medicine. They are primarily concerned with ensuring that whatever treatments are applied to animals, they are exclusively the purview of veterinarians, a position which has some legitimacy in terms of consumer protection but which also smacks greatly of simple economic protectionism.

Attempts by professional organizations to oppose quack therapies have been made in the past, and these have been met with legal and political counterattacks that have had devastating effects. The American Medical Association once tried to suppress the use of chiropractic for both scientific as well as, admittedly, less laudable reasons. The organization lost an anti-trust lawsuit as a result, and quickly got out of the business of aggressively trying to promote scientific standards where CAM was concerned. And the very existence of the Dietary Supplement Health and Education Act and the National Center for Complementary and Alternative Medicine, both political constructs that have effectively protected unproven and bogus therapies despite all scientific evidence against them, is testimony to the inability of the political process to supervise anything like rational scientific standards for medical practice.

The amount of time this particular vet spends responding to skeptical criticism (albeit without providing any facts or sound arguments to counter it) seems to me to be a good sign. It demonstrates that even the most committed proponents of alternative medicine recognize that such criticisms have weight and influence. We will never banish irrationality, but the fact that even CAM proponents attempt to claim that science is behind their approach and that they often attempt to employ the language, if not the methods, of evidence-based medicine indicates that even they recognize that the public believes and trusts science more than they would like us to think. The facts, unfortunately, do not speak very loudly or effectively for themselves, so we who are committed to scientific medicine must speak for them.

Evaluating Medical Advice and Credentials on the Internet

Monday, May 24th, 2010

Dr. Susan Wynn, a veterinarian and veterinary nutritionist who promotes “holistic” veterinary medicine, has put up a couple of blog posts recently which I rather liked, so I thought I’d comment briefly on them. I more commonly find myself disagreeing with Dr. Wynn on questions of veterinary CAM, but she does often present a more rational and scientific approach to the subject than most proponents of “integrative” medicine, and I appreciate the few opportunities that arise to find common ground with those who have a different perspective or approach.

The more recent of the two posts consists of advice on how to critically evaluate veterinary medical information on the internet. I have also written about this subject, and I agree wholeheartedly with Dr. Wynn’s comments. The recommendations generally focus on being wary of excessively optimistic or unrealistic claims, sites with a commercial or rigid ideological bias, sites which rely on testimonials in place of properly published and relevant scientific research, and sites which refuse to disclose relevant information, such as the ingredients in the remedies they sell or the qualifications of the people offering advice. All of this is sound advice when looking for medical information on the Internet.

Dr. Wynn also published a post on the subject of evaluating the credentials of those offering veterinary medical advice, How to Avoid Phony Practitioners. For the most part, I agree with her advice on this subject as well, with an important exception I’ll get to in a moment. It is easy to make up impressive-sounding titles and initials, and not much harder to obtain a meaningless advanced degree through fake diploma mills, and this is common practice among those pushing alternative medical therapies. Not too long ago, I wrote about Primal Defense, a probiotic product marketed by Jordan Rubin, a charlatan who routinely tried to give his advice additional gravitas by acquiring fake degrees from unaccredited correspondence schools. If one is going to seek advice on veterinary medicine, it makes sense to give more weight to the advice of someone with years of training in veterinary medicine. Doctors are just as prone to cognitive errors as anyone else, of course, but we have the advantage of getting much of our information from the most reliable source available, scientific research.

My only disagreement with Dr. Wynn’s advice is that it ignores the importance of evaluating not only the quality and rigor of the training a practitioner receives, but also the plausibility and evidence for the subject matter in which they are trained. A credential from a rigorous and well-supervised program teaching astrology or witchcraft is not worth any more than a diploma mill credential since the approach is itself nonsense, and an expert in nonsense isn’t an expert in any meaningful sense of the word.

Dr. Wynn talks particularly about the various levels of credentialing in Naturopathy, but she completely neglects the fact that the discipline itself is a pseudoscientific, faith-based approach to medicine. In principle, naturopathy is a vitalist philosophy that looks to unseen energy forces to explain health and disease. In practice, it is a hodgepodge of sensible nutritional and exercise advice and loads of CAM, varying from the plausible-but-unproven to the completely bogus. The only common theme to methods used by naturopaths seems to be the notion of vital energies of one kind or another, as found in methods such as acupuncture, chiropractic, and homeopathy, which all rely in theory on mystical energies that no one can prove exist. And while naturopaths are theoretically trained to refer patients with serious medical conditions to conventional doctors, many are suspicious of conventional drug and surgical therapies. It is not uncommon for naturopaths to oppose vaccination and to promote not only supposedly “natural” approaches such as herbal medicine but also bizarre, dangerous, and manifestly “unnatural” therapies such as chelation therapy, detoxifying enemas, and so on. If the theory is nonsense and the specific practices unscientific, it doesn’t matter how rigorous the training is.

The same logic applies to Traditional Chinese Medicine, with it’s vitalist theory, idiosyncratic and unscientific diagnostic methods, and inconsistent and mostly unproven therapeutic practices. Chiropractic, likewise, contains a few bits of useful treatment for musculoskeletal pain and a load of nonsense and outright dangerous practices, and of course homeopathy is utterly worthless.

All the training in the world in a philosophy or method which has no value does not protect the patient from harmful or useless treatments. So while I generally agree with Dr. Wynn in terms of checking into the credentials of anyone offering veterinary medical advice, I would go farther and suggest that pet owners should look into the arguments and, most importantly, the scientific evidence concerning the philosophy and methods a particular practitioner offers as well.

Spinmaster Messonier at it again

Sunday, April 25th, 2010

I recently discussed, and corrected, some comments Dr. Shawn Messonier made on his blog concerning Alison Averis’ post here illustrating how personal experience can be unreliable in evaluating whether a medical treatment works or not. Dr. Messonier has responded to some of the comments I made in that post, as usual trying to warp them to fit his pro-CAM “talking points.” He begins by dredging up that vacuous marketing label of “healthcare choice” which I’ve discussed before.

While most doctors and healthcare providers are open to natural care and support your choice and the type of medicine you desire, sadly there are still many that will come up with any argument and do anything to prove to you that your choice is wrong.

This argument presumes that giving people more therapies to chose from, even if they are useless or even harmful, is somehow a good thing. It also suggests that informing people about what reliable, scientific evidence is and how they can use it to help them make good choices for their pets is somehow limiting the freedom or autonomy of pet owners.

I offer choices to my clients every day, and I expect them to be full partners in caring for their pets. I do not offer them the option of psychic diagnosis or therapy, animal sacrifice to propitiate the gods of health, or homeopathy because those would be false choices of no real value. And if there is a therapy that I believe might be beneficial but about which there is significant uncertainty, I give them that information so their choices will be informed. Adding meaningless buzzwords like “natural” to what one does, regardless of whether there is reliable evidence to support that it is safe or effective, is purely a marketing strategy, not a means to give greater autonomy or choice to pet owners.

Dr. M then goes on to quote my recent post and respond to specific bits and pieces.

1.“Doctors rely on their personal experiences, intuition and, anecdotes as evidence to justify implausible or simply “made up” theories and practices.”

This is partly true, but it’s also true for doctors who practice conventional medicine as well. In the good old days before strictly controlled, well-funded (usually by the drug companies seeking approval for their latest drug) studies, ALL doctors learned and shared knowledge based upon their personal experiences with various medications (both natural and conventional.) There is nothing wrong with learning from experience and sharing these experiences. Yes, we all would love to have well researched studies “proving” what we already know to be factually correct. However, the company funding the study determines which studies are ultimately published. While most companies are ethical, there have been some well-publicized incidents of companies ignoring negative studies and only publishing positive studies showing benefits for their medications.

*Evidence is evidence. Either a treatment works or it doesn’t. While skeptics selectively ignore evidence showing the effectiveness of natural therapies, they never seem to ignore evidence showing natural therapies don’t work.

Several problems here. First, Dr. M is unfortunately correct that many doctors practicing primarily conventional medicine rely unduly on anecdote and personal experience. This does not, of course, mean it is the right approach, and I hope that the practice of science and evidence-based medicine will come to be the predominant approach to medical knowledge among all veterinarians. It is certainly more likely to take hold among those who already practice medical approaches that are based on sound scientific reasoning and evidence than among those who, like Dr. M, confidently assert the value of therapies that are unscientific in their underlying premises or without good supporting evidence. I certainly do not claim perfection in conventional medicine, I simply advocate for all of us as veterinarians and pet owners to recognize our limitations and attempt to do better by turning to the most reliable evidence available concerning the therapies we use.

The underlying problem with the CAM approach to knowledge is explicit in this statement. Dr. M pays lip service to scientific evidence, but he clearly views it as icing on the cake, “‘proving’ what we already know to be factually correct.” The arrogance of this kind of self-certainty is breathtaking. Science and the knowledge it generates is not merely a way of better promoting and marketing what we already believe. It is a way of finding the truth despite our own limitations and cognitive biases. There can be no learning or improvement without the recognition that our knowledge is incomplete and flawed, and yet Dr. M clearly does not believe this. To him, science is simply another tool in the promotion of his beliefs, not a way to find out what is true and what isn’t.

As far as the issue of funding bias and publication bias, there is no question these are real problems. They do not, however, invalidate the whole enterprise of scientific research, as the good doctor suggests. There is plenty of research evidence available, both from industry-funded research and from other sources (academia, government, private clinical practices, etc), and acknowledging that there are weakness in some of this research is not license to ignore it and simply do what we feel like doing.

“Evidence is evidence” is nonsense. There are levels of evidence ranging from the least reliable (personal opinion and experience) to the most reliable (multiple consistent well-designed and conducted clinical trials). The problem many CAM practitioners have is reading the pyramid of evidence upside down:

Undoubtedly, we all suffer from confirmation bias, so it is true we attend to evidence that supports our beliefs more than evidence that disconfirms them. This is a major reason why scientific evidence is more reliable than anecdote and personal experience, so raising the issue simply undermines Dr. M’s own approach. If he has specific evidence for particular therapies he thinks I am ignoring, his is of course always welcome to provide it for consideration.

2.“I would be very interested in how much “objective” measuring of outcomes doctors using natural therapies actually do. They often seem to imagine they can “eliminate” subjective owner assessments in practice, but I find this hard to believe.”

Let me quickly answer this objection by sharing with you two recent cases. One involves a dog with elevated kidney enzymes that did not respond to treatment by his prior conventional veterinarian. The other case involves a cat with elevated liver enzymes and also did not respond to treatment by her conventional veterinarian. After using several natural therapies, follow-up blood tests showed that the kidney and liver enzymes returned to normal.

There is nothing subjective about this. The laboratory, which did not know what kind of therapy I used on these patients, reported the results objectively.

Even in trying to show how objective his medical practice is, Dr. M cannot help but rely on anecdotes to prove his point. Of course, the flaw here is glaringly obvious. He assumes that improvements in the clinical laboratory values measured was due to his therapy. This is the post hoc ergo propter hoc fallacy, and it ignores the fact that medical problems can improve for all sorts of reasons other than the ones we assume. Some possibilities include:

1. Self-Limiting Disease Many diseases are self-limiting. If the condition is not chronic or fatal, the body’s own recuperative processes usually restore the sufferer to health. Thus, to demonstrate that a therapy is effective, its proponents must show that the number of patients improved exceeds the number expected to recover without any treatment at all. Without detailed records of successes and failures for a large enough number of patients with the same complaint, someone cannot legitimately claim to have exceeded the norms for unaided recovery.

2. Waxing and Waning Chronic Disease
(also known as Regression to the Mean) Such conditions as arthritis, allergies, and gastrointestinal problems normally have “ups and downs.” Naturally, clients tend to seek therapy during the period or greatest clinical symptoms. In this way, a treatment will have repeated opportunities to coincide with upturns that would have happened anyway.


3. Multiple Concurrent Therapies If improvement occurs after a pet has had several interventions, and probably other unremarked changes in the owner’s treatment of the sick pet, one or another of the changes often gets a disproportionate share of the credit or blame. Frequently, the latest in a series of interventions or the newest thing tried is credited with improvement even though many things were done.

The overall tone of Dr. M’s response is that I am somehow on a crusade against “natural” medicine. That cannot be true for the simple reason that “natural medicine” is a meaningless term filled with assumptions and the naturalistic fallacy. I am actually on the same crusade as Dr. M. I am dedicated to giving my patients the best, most effective care and the highest quality of life possible, and to protecting them from things that are useless or harmful. The difference is not one of intention, but one of philosophy. I believe there is such a thing as truth and that the best way to  care for our pets is to know what is true and what is false about the therapies we offer. I believe that we often don’t know what we think we know, and that our confidence in our own intuition and judgments is often excessive and unjustified. I believe that science is the most powerful tool we’ve ever invented for separating truth from mythology, and that with it we have done, and will continue to do, better in medicine that we did in all the thousands of ears we relied exclusively on storytelling, respect for tradition and authority, and random trial and error to decide what works and what doesn’t.

If this blog is controversial or challenging, it is because when I find the evidence doesn’t support the claims people make about veterinary medicine I have the temerity to say so. I try to do so in a civil way, and I try to focus on the problems of reasoning and evidence rather than personality, though I won’t claim I never give in to irritation at the persistence of mischaracterization and misinformation in some people’s arguments. But helping pet owners to take better care of their companions isn’t accomplished by ignoring the evidence or by letting unsupported claims or misleading arguments stand, and I make no apologies for trying to help people filter the information available to them and separate the strong, reliable claims from the weak or thoroughly bogus ones. I’m happy to discuss what the evidence is and what it means with anyone, but Dr. M prefers simply to insinuate and allege motives, to throw around meaningless marketing terms, and to talk about anything but the specific evidence for or against the therapies he advocates.

Dr. Shawn on Alison Averis’ Essay Fooling Yourself

Friday, April 16th, 2010

The tireless promoter of “natural” veterinary medicine (whatever that is) and himself, Dr. Shawn Messonier, has applied his characteristic fuzzy logic and love of strawmen and misleading hyperbole to a recent guest post by Alison Averis on Fooling yourself: An example of how to fool yourself and how the placebo effect can work in animals. I shall reproduce his post below, with appropriate commentary and clarification (in bracketed, boldface type).

“I recently came across a post on another blog purporting to show that there is no proof that natural/alternative therapies work. [Actually, actually reading Alison's post will make it clear that this is not the point of it at all. Throughout his essay, Dr. Shawn seems unable to distinguish between an anecdote used appropriately as an illustration and example of a phenomenon, and his preferred use of it as proof of something. Alison's story was a parable illustrating how easy it is for one's expectations to color one's judgment about the efficacy of a therapy not evaluated in an objective, scientific way, not a statement or proof that "natural/alternative" therapies do not work.] This particular blog is devoted to debunking any therapy that falls outside the mainstream. [Actually, this blog is devoted to, as it says at the top of the page, taking a "Science-Based Look at Complementary and Alternative Medicine." I am happy to validate any non-mainstream therapy that can be demonstrated to be effective in an appropriately scientific way, and I am equally happy to condemn any mainstream therapy that cannot.] The writer of this blog constantly seeks to show that there is no proof that any natural therapy ever works or helps anyone or any pet. [strawman and flagrant demonization]

The post I read was submitted by a reader of this particular blog. Briefly, she shared the following information in her post.
An “alternative therapist” told the owner of a horse that she would “work on” the horse for free if the owner would give her feedback on how the horse performed following the “free therapy session.” Unknown to the owner, the “therapist” never worked on the horse but led the owner to believe she had done so.

The day following the supposed “therapy,” the owner was happy to report that the horse actually “rode better than normal.” The writer of the blog used this one example to prove that natural therapies don’t work and that the reason the owner thought the horse rode better was simply due to the power of suggestion, or the placebo effect. [Again, the example was never purported to prove that "natural therapies," or even the specific therapy referred to, don't work. It was intended to illustrate how subjective, uncontrolled observations are an unreliable basis for making a judgment on what works and what doesn't.]

While this was an interesting post to read, and it can easily deceive people into thinking that this one simple experiment proved that all natural therapies only work by the placebo effect, a more careful examination of the post leaves a lot to be desired.

First, I don’t know what an “alternative therapist” is or what one does. I assume the writer of this blog is referring to some sort of physical therapy such as massage therapy, but that is never explained.

Second, there’s a big difference between someone who claims to be an “alternative therapist” and a licensed doctor trained in integrative medicine. [How, exactly, does one get "licensed" to practice "integrative medicine?" This is a buzzword that simply means the use of unproven therapies alongside scientifically validated ones, and there is no process by which one becomes licensed to do this.]

Third, this particular website on which the blog appears always chastises alternative medicine for the lack of proof for alternative therapies since there are so few well controlled, double-blind placebo-controlled studies. [I have rebutted this charge of relying only on double-blind placebo controlled trials before HERE, yet Dr. Shawn continues to state the falsehood that I rely solely on such evidence.] It’s interesting that this website now uses an example of a poorly designed “study” (if an observation of one patient even constitutes a study) to prove that no natural therapies ever work! [Yet again, the hypocrisy that he gleeful implies is not present, despite his inability to distinguish an example from a proof.]

Fourth, the observation in this case was entirely subjective rather than objective. Rather than using an owner’s observation that the horse “rode better” after a particular therapy, why not use a more objective measurement such as gait analysis or forced plate analysis? In my practice, I can objectively measure things such as a pet’s blood pressure or blood count and easily determine if my therapy (conventional or natural) is working. This can totally eliminate the subjective assessment an owner may make in determining if a pet simply “feels better.” [I would be very interested in how much "objective" measuring of outcomes Dr. Shawn actually does. He seems to imagine he can "eliminate" subjective owner assessments in his practice, but I find this hard to believe. He routinely claims better outcomes for his patients with cancer, for example, than those possible through scientific medicine, yet I am unaware of any formal, scientifically controlled or objective research he has published on the subject, so I wonder how exactly he makes his assessments of his interventions more objective and independent of owner history than the rest of us in clinical practice.]

Fifth and finally, the same “conclusion” could easily be reached in this case if a conventional drug had been used rather than an alternative therapy. For example, suppose a doctor told the same horse owner that he was going to give the horse a pill which would improve its performance. But suppose the doctor secretly did not give the horse the medication but the owner still reported that the horse “rode better” the next day. If we follow the blogger’s (lack of) logic, we have to draw the same conclusion-namely that this one example proves that conventional drug therapy doesn’t work! [No, as I've made clear, and as should be obvious from reading the post, the conclusion we would draw would be that the owner report of how the horse performed subsequent to the sham therapy, be it conventional or alternative, is not a reliable assessment of the efficacy of the therapy. The point is that we must have a better level of evidence, and my evaluations of alternative practices such as those advocated by Dr. Shawn is intended to identify whether such evidence is or is not available. He is the one who routinely relies on his personal experiences and intuition and anecdotes as evidence to justify implausible or simply "made up" theories and practices. The whole purpose of this blog is to do better than this sloppy and outdated approach, not to replicate it in favor of or in opposition to any particular therapy.]

It’s interesting how much hatred and negativity one encounters among people who don’t like natural/alternative medicine. [It is also interesting to see how reasoned and civil criticism and a call for real evidence rather than simply opinion is identified as "hatred and negativity."] To use one example as this blogger has done as universal proof that integrative medicine doesn’t achieve successful results is ludicrous and deceiving. [And, fortunately, not at all what has been done with this example] Fortunately, it’s easy to see through all the hypocrisy in this blog and understand the real goal of people who write this rubbish-destroy your choice in determining what kind of therapy you would like for you, your family members, and your pets. [Wow, "rubbish." There's a polite and thoughtful critique for you. As for the question of choice, I've addressed this bit of misdirection before. Offering as alternatives treatments which have not been demonstrated to be safe or effective, or which have actually been clearly demonstrated not to be so, is not offering choice--it is offering false hope at best and lies at worst, and these are not what our patients or clients deserve from us.]“

Nice Post on Equine CAM by Alison Averis

Friday, March 26th, 2010

Being a small animal  vet, I don’t have much first-hand experience with equine CAM. But our recent guest blogger, Alison Averis, is very involved in equine issues, and she has a nice article in the Equine Independant on judging alternative claims in this area. She is also dealing with the usual sorts of critiques that defend CAM and challenge science-based medicine without ever resorting to facts or evidence but trying to find fallacious rhetorical strategies to undermine arguments without addressing them. She’s holding her own just fine, but it wouldn’t hurt to offer her some support if you can, particularly those of you more familiar with horse medicine.

129th Skeptics’ Circle!

Wednesday, January 27th, 2010

Good eveni…Is this on? Can you hear me in the back? Good, ok. Good evening ladies and gentlemen, and welcome to the 129th meeting of the Skeptics’ Circle. I’m SkeptVet, and I’ll be your MC this evening. Sorry, it’s my first time as MC, so I’m a bit nervous. Anyway, my Toastmaster’s class said I should open with a joke, so here goes..

I ran into Shirley McClain the other day, and I asked her, “Why did the chicken cross the road?”

She told me, “A chicken doesn’t cross the road when it crosses the road, and we know this because Stephen Hawking says we understand energy.”

Thank you, thank you, yes I’m here all week. For more skeptical chicken and road mockery, check out the ultimate collection at Skeptico.

Ok, we have a great lineup tonight, so let’s get right to it.

The august Dr. Aust considers the needs of those suffering from the recent earthquake in Haiti and suggests that while maybe sending money to aid organizations is a quiet, anonymous, not terribly dramatic way to help, it is better than arrogantly and flamboyantly rushing there to show off your woo, as some homeopaths have done. And now for something completely different (how many of you are old enough to remember that show?!) he takes an informative and surprisingly lighthearted look at Hitler and homeopathy.

Speaking of Haiti, I think we all know Pat Robertson had a few words to say on the subject. Well, The Skeptical Teacher has a few words to say back. Amen, brother! And on the subject of homeopathy, ST brings us a not-so-tragic story of one of our own, skeptic and atheist blogger Ziztur, who overcome by the meaninglessness of life (or by realization of the eternal gullibility of human beings) attempts to commit suicide with a homeopathic sleep aid. An entertaining and instructive, if futile gesture! Finally, The Teach also brings us a clip of Captain James T. Kirk interviewing someone even farther out in space than himself, psychotic–er, I mean–psychic John Edward. Set phasers for debunk!

And because woo is a global phenomenon, we have Stuff and Nonsense across The Pond pointing out the potential for confusion when discussing homeopathy and herbal remedies. Most homeopathic remedies are so dilute that they contain nothing but water and the hopes of their befuddled proponents. However, herbal remedies actually contain active compounds, for good or ill. Unfortunately, the two types of nostrums share many marketing points, including buzzwords like “natural,” which make it easy for consumers to confuse the two, with potential dangerous results.

Next, Akusai  at Action Skeptics takes on a subject I’ve also been known to rant about from time to time; the depressing decline in the quality of the Discovery Channel, from decent nature documentaries to “reality-TV” dreck and woo promotion. There are a few decent shows left, and Akusai reviews these and the rest in Discovery Channel- The Good, the Bad and the Ugly. Oddly enough, The Onion had a related story today entitled Science Channel Refuses to Dumb Down Science Any Further.

It’s been a tough winter already, but when not shoveling snow, Don Reifler of The Lafayette Skeptics has put together a comprehensive video presentation on the history of anti-vaccine activists called The March of the Mercury Militia which should be required background for anyone dealing with this particular anti-science bunch.

In the much warmer clime of South Africa, a nice local test of electromagnetic hypersensitivity syndrome I described by Paul Hutchinson, along with the disappointing lack of interest shown by sufferers in the results.

PodBlack Cat has for us an entertaining look at Superstition and the Olympics.

And continuing our look at medical nonsense, Bing over at Happy Jihad’s House of Pancakes has some thoughts to share with Grand Woomeister Mike Adams regarding his recent incoherent rant against skepticism, a temper tantrum precipitated by his losing to Dr. Rachel Dunlop (aka Dr. Rachie) for the Shorty Award in Health. These thoughts are incisive and cogent, and at least PG-13. Bing also has a proposal for an International Dr. Rachie Appreciation Day that merits serious consideration. I’ve taken the liberty of including a post from Dr. Rachie herself, showing a rare example of regulatory oversight actually calling BS on claims. And finally, Bing shares a few snapshots from his tour of the Creation Museum.

Also fighting the good fight against the imposition of the dangerous irrationality of religious fundamentalism on the rest of us, Ron Britton at the Bay of Fundie continues his extensive analysis of the Darwin Was Wrong “Conference”, which he infiltrated in November. Part 9: Fossil Fraud deconstructs the laughable attempts of one of the conference speakers to demonstrate why the fossil record is just God’s little joke, so we must abandon the notion of evolution all together. Good luck with that!

We get to enjoy three posts from Andrew Bernardin at Evolving Mind this time! First, he dissects the fuzzy “science” behind a study of the effects of stress after the Katrina disaster on children. Next, he shows us the connection between the anthropic principle and drunken billiards. Finally, he uses a bit of consumer research to help explain why good solid science is harder to market than vague nonsense.

Cubik’s Rube tells a wrenching horror story about Facilitated Communication and then follows it with a detailed and intelligent analysis of this practice and its implications. An excellent resource to point the credulous towards, and an excellent example of how to connect with people’s emotions to make them care about an issue without sacrificing reason and fact.

Who can foresee what the fickle winds of Fate will bring? In an unexpected stroke of good fortune, Lord Runolfr has won a valuable prize! Or has he…?

But wait! Perhaps the future isn’t so opaque after all. Hear Ye, Hear Ye! Red Stick Skeptic has had a vision! He has cast aside self-doubt and bravely proclaimed his ability to see the future, and woe to those who ignore his prognostications! I know all you closed minded skeptics out there are going to be keeping score, but I’ll bet he at least beats Sylvia Brown!

Well, I’m afraid that’s all we have time for tonight. I’m so glad we’ve had this time together. Just to have a laugh and sing a…What? Oh, sorry I thought I was supposed to sing.

The next Skeptics’ Circle, will be held at The Lay Scientist February 11, 2020. Please send more good stuff their way, at layscience@googlemail.com.

OK, good night everybody! Thanks for coming! Don’t forget to tip your waiters!

CAM=Miracles, Science=Death?

Sunday, January 24th, 2010

I really shouldn’t be giving this guy so much attention, but after our little tiff I’ve taken to checking in on his blog, and the vicious and self-serving marketing strategy is offensive enough to stimulate a response. Dr. Shaw Messonnier (is that French for Messiah? You’d think so from his latest blog and new book) is continuing his tirade against veterinarians who stubbornly cling to science over faith-based medicine. His most recent blog post is still combining the blatantly unethical and deceitful mischaracterization of science-based veterinary medicine with the self-serving plugging of his own practices, and his book.

“Every day I see pets whose owners share with me the same tragic story. Their veterinarians have told them there is nothing they can do to help their pets. Many of these pets were seen by their veterinarians for routine checkups or what appeared to be minor problems. During the visit, a serious condition, often cancer, was diagnosed. As a result of the seriousness of the disease, the veterinarian offered no hope. Instead, the veterinarian told the owners that their pets had only a few weeks to live and recommended euthanasia when the pets’ condition declined.”

Of course, honestly discussing the inevitability of death is taboo in our culture, and while scientific medicine has much to offer in the treatment of cancer, and outperforms alternative methods whenever real tests are done (and this study), the reality is that some diseases cannot be cured and treatment must focus on maintaining comfort and a good quality of life. And the ultimate act of care for terminally ill pets is to let them die peacefully and without pain, rather than suffer the frequently awful and prolonged experience of an unaided death.

But Dr. Messonnier prefers confidently offering false, unsubstantiated claims of miraculous benefit from his methods (including diets free of supposed “toxins,” unproven or disproven nutritional supplements to “boost the immune system,” and of course avoiding “unnecessary” vaccinations). He makes wild and unsubstantiated claims about the success of his own methods, based solely on his opinion of what a great doctor he is. For example, “In general, pets treated with a combination of conventional medications plus natural therapies will usually live 2 to 3 times as long as those whose treatment does not include natural therapies.” This seems odd considering the evidence that in human cancer patients alternative medicine may actually be associated with shorter survival, either because of the effects of the CAM therapies themselves or because patients turn to CAM when they have diseases for which no real therapies exist. Still, he insists, “Integrative/holistic/natural/green therapies can offer “hope for the hopeless.” While I can’t always cure all of my patients, I can offer all of them hope and make them healthier. It is not uncommon for me to treat a pet who is given weeks to live by the previous veterinarian and have that pet live many months or even several years!”

In addition to such fanciful “clinical impressions,” and false hope, Dr. Messonnier bases his marketing strategy on mischaracterizing mainstream medicine, with all the cliches about real medicine only treating symptoms an CAM creating health, and so on: “The reason for my success? Unlike conventional doctors, I focus on HEALING the pet rather than TREATING the disease. This is a foreign concept to many doctors. When I was in veterinary school, I was taught to diagnose and treat disease. Our goal was never to improve the health of the pet but simply to win the battle against the disease. When that is not possible, the only other alternative is euthanasia.”

Not surprisingly, the rant ends with a plug for his new book: Unexpected Miracles-Hope and Holistic Healing for Pets. I have no doubt this will be a touching and emotion collection of anecdotes which create the impression, false though it is, that his methods can save those who we closed-minded and ineffectual science-based practitioners have given up on. Despicable and deceitful nonsense couched in the self-righteous language of the enlightened bringing hope and compassion to those abandoned by the cold and heartless practitioners of  mainstream medicine. Truly, if it were possible Dr. Messonier should feel ashamed.

Dr. Shawn Kerfuffle Update

Thursday, January 21st, 2010

I notice that Dr. Messonier has deleted  my response to his blog post defaming me. I guess polite, reasoned criticism is intolerable to him.

He has also written another post full of strawmen and cliches. He begins by trying to make his readers believe science-based veterinarians live in a fantasy world where nothing is done that is not validated by rigorous clinical trial evidence: “According to the skeptics, unless the therapy has been proven to work through numerous rigidly controlled scientific studies, they would be considered “alternative and unproven therapies” that should not be used in the practice of medicine.” Of course this is nonsense, and attacking a position your opponent doesn’t hold is vacuous rhetorical trickery.

A good definition of evidence-based medicine, which I have often quoted, is “the integration of the best research evidence available with clinical expertise as well as the unique needs or wishes of each client in clinical practice.” Clearly, no one is arguing that we should never do anything unless it has been validated by good clinical trials. The point of evidence-based medicine is simply to organize the evidence in a hierarchy from least reliable (anecdote, personal impressions) to most reliable (replicated and well-designed clinical trials), and to weight most heavily the highest quality evidence available for a given intervention. Obviously, this is too complicated for Dr. Messonier, who prefers to paint an image of an imaginary bogeyman called the “The Skeptic,” which he then pastes over the face of anyone with the temerity to suggest his personal experiences might be mistaken.

He goes on to accuse conventional veterinarians of choosing to kill pets rather than admit their methods have failed and refer their patients to someone, like him, who has the power to help them. How’s this passage for self-aggrandizing, closed-minded, mean-spirited mischaracterization of those who disagree with him?

“I’m still bewildered by the fact that many conventional veterinarians choose euthanasia as a solution for failure of their conventional treatments, rather than simply opening their minds to the healing power that exists when using clinically proven, time-honored natural therapies. My hope is that more owners will continue to seek doctors, for themselves and their pets, who are open-minded to doing what is in the best interest of the patient regardless of which therapy ultimately proves successful, or which one has been “proven” to work by artificially designed controlled studies.”

Note the use of “clinically proven” to mean “I think it works.” And the use of “proven” in scare quotes to denigrate the conclusions of scientific evidence. Then there’s the usual meaningless cliché “time-honored natural” to describe blind faith in tradition combined with the naturalistic fallacy. And finally we have the blithe dismissal of clinical trials as “artificially designed controlled studies.”

This is a portrait of a mind closed to any suggestion of its own fallibility and blind to the history of medicine in the last 200 years, which has seen progress in well-being unlike the previous total of human history thanks to the “artificial” methods of science. This is a doctor so certain that he is right that disagreeing with him is intolerable and must be denounced, with all the self-righteousness of the religious fanatic, as a willful refusal to see the truth that he sees so clearly.

Of course, civil debate about the facts of specific medical interventions is impossible with such an attitude. He’s never once tried to convince me of anything, merely taken my suggestion that his epistemology is flawed as a personal affront and gone on a tirade against a cartoon image of me and other veterinarians who don’t placidly accept his view. The best one can hope for in such situations is that, as he suggests, pet owners will listen to the quite different approaches we represent and decide for themselves where the best hope for their pets lies. I have no doubt Dr. Messonier is genuinely convinced he is offering the best medicine, and I have very little doubt that he is mistaken. However, I agree with him at least so far as to believe pet owners can see through closed-minded nonsense. I just happen to believe that will lead them towards scientific, evidence-based medicine rather than “time-honored” woo.