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  1. skeptvet says:

    I haven’t yet written about this therapy, largely because there is little evidence either way and no strong conclusion about efficacy in dogs is possible. Here are a few reviews elsewhere:

    American Academy of Orthopedic Surgeons

    Arthroscopy. 2016 Mar;32(3):495-505. doi: 10.1016/j.arthro.2015.08.005. Epub 2015 Oct 1.
    Efficacy of Intra-articular Platelet-Rich Plasma Injections in Knee Osteoarthritis: A Systematic Review.
    Meheux CJ1, McCulloch PC1, Lintner DM1, Varner KE1, Harris JD2.
    Author information
    Abstract
    PURPOSE:
    To determine (1) whether platelet-rich plasma (PRP) injection significantly improves validated patient-reported outcomes in patients with symptomatic knee osteoarthritis (OA) at 6 and 12 months postinjection, (2) differences in outcomes between PRP and corticosteroid injections or viscosupplementation or placebo injections at 6 and 12 months postinjection, and (3) similarities and differences in outcomes based on the PRP formulations used in the analyzed studies.
    METHODS:
    PubMed, Cochrane Central Register of Controlled Trials, SCOPUS, and Sport Discus were searched for English-language, level I evidence, human in vivo studies on the treatment of symptomatic knee OA with intra-articular PRP compared with other options, with a minimum of 6 months of follow-up. A quality assessment of all articles was performed using the Modified Coleman Methodology Score (average, 83.3/100), and outcomes were analyzed using 2-proportion z-tests.
    RESULTS:
    Six articles (739 patients, 817 knees, 39% males, mean age of 59.9 years, with 38 weeks average follow-up) were analyzed. All studies met minimal clinical important difference criteria and showed significant improvements in statistical and clinical outcomes, including pain, physical function, and stiffness, with PRP. All but one study showed significant differences in clinical outcomes between PRP and hyaluronic acid (HA) or PRP and placebo in pain and function. Average pretreatment Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores were 52.36 and 52.05 for the PRP and HA groups, respectively (P = .420). Mean post-treatment WOMAC scores for PRP were significantly better than for HA at 3 to 6 months (28.5 and 43.4, respectively; P = .0008) and at 6 to 12 months (22.8 and 38.1, respectively; P = .0062). None of the included studies used corticosteroids.
    CONCLUSIONS:
    In patients with symptomatic knee OA, PRP injection results in significant clinical improvements up to 12 months postinjection. Clinical outcomes and WOMAC scores are significantly better after PRP versus HA at 3 to 12 months postinjection. There is limited evidence for comparing leukocyte-rich versus leukocyte-poor PRP or PRP versus steroids in this study.
    LEVEL OF EVIDENCE:
    Level I, systematic review of Level I studies.

  2. Sabra says:

    I tried to contact you before, but I don’t think it worked. I can’t find answers to these questions anywhere. If you could help me, that would be great, but if you don’t have time, could you at least let me know if you answer them on your blog? They are not really related, but here they are.
    What is the difference between Plaqueoff for dogs and ordinary kelp granules? Does the bacteria on marine algae truly soften plaque, and if it does, is there a way to get the same effect without the iodine risks of kelp?
    Assuming you can get your dog to drink it, does the Nyla bone water additive do anything other than freshen breath? Also, what is this denta-c referenced in the water additive, breath spray, and foaming tartar remover?
    Can the probiotics in kefir survive your dog’s stomach acid? I know the probiotics and yogurt can survive in humans, but the pH levels are different.
    If digestive enzymes help dogs with pancreatic insufficiency, why can’t they help dogs with food sensitivities?
    Even though the myth about collagen isn’t true, are there any benefits to giving a dog gelatin?
    If liquid fish oil causes reduced shedding in my dog, is it really helping, or just masking the symptoms of an allergy?
    Do dogs need sunscreen?
    Where did the slim doggy App get caloric information for various exercises like swimming, when the only research that has ever been done involves dogs that were running? If they are using human caloric information, which won’t work because dogs metabolize food differently and pull more energy from fat, can they get in trouble for fraudulent marketing? Because there is no research, how are you supposed to know how many calories your dog is burning through exercise if you want to maintain the weight through more than just guesswork?
    Art turmeric and mushroom extract beneficial to dogs?

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