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I haven’t yet written about this therapy, largely because there is little evidence either way and no strong conclusion about efficacy in dogs is possible. Here are a few reviews elsewhere:
American Academy of Orthopedic Surgeons
Arthroscopy. 2016 Mar;32(3):495-505. doi: 10.1016/j.arthro.2015.08.005. Epub 2015 Oct 1.
Efficacy of Intra-articular Platelet-Rich Plasma Injections in Knee Osteoarthritis: A Systematic Review.
Meheux CJ1, McCulloch PC1, Lintner DM1, Varner KE1, Harris JD2.
To determine (1) whether platelet-rich plasma (PRP) injection significantly improves validated patient-reported outcomes in patients with symptomatic knee osteoarthritis (OA) at 6 and 12 months postinjection, (2) differences in outcomes between PRP and corticosteroid injections or viscosupplementation or placebo injections at 6 and 12 months postinjection, and (3) similarities and differences in outcomes based on the PRP formulations used in the analyzed studies.
PubMed, Cochrane Central Register of Controlled Trials, SCOPUS, and Sport Discus were searched for English-language, level I evidence, human in vivo studies on the treatment of symptomatic knee OA with intra-articular PRP compared with other options, with a minimum of 6 months of follow-up. A quality assessment of all articles was performed using the Modified Coleman Methodology Score (average, 83.3/100), and outcomes were analyzed using 2-proportion z-tests.
Six articles (739 patients, 817 knees, 39% males, mean age of 59.9 years, with 38 weeks average follow-up) were analyzed. All studies met minimal clinical important difference criteria and showed significant improvements in statistical and clinical outcomes, including pain, physical function, and stiffness, with PRP. All but one study showed significant differences in clinical outcomes between PRP and hyaluronic acid (HA) or PRP and placebo in pain and function. Average pretreatment Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores were 52.36 and 52.05 for the PRP and HA groups, respectively (P = .420). Mean post-treatment WOMAC scores for PRP were significantly better than for HA at 3 to 6 months (28.5 and 43.4, respectively; P = .0008) and at 6 to 12 months (22.8 and 38.1, respectively; P = .0062). None of the included studies used corticosteroids.
In patients with symptomatic knee OA, PRP injection results in significant clinical improvements up to 12 months postinjection. Clinical outcomes and WOMAC scores are significantly better after PRP versus HA at 3 to 12 months postinjection. There is limited evidence for comparing leukocyte-rich versus leukocyte-poor PRP or PRP versus steroids in this study.
LEVEL OF EVIDENCE:
Level I, systematic review of Level I studies.
I tried to contact you before, but I don’t think it worked. I can’t find answers to these questions anywhere. If you could help me, that would be great, but if you don’t have time, could you at least let me know if you answer them on your blog? They are not really related, but here they are.
What is the difference between Plaqueoff for dogs and ordinary kelp granules? Does the bacteria on marine algae truly soften plaque, and if it does, is there a way to get the same effect without the iodine risks of kelp?
Assuming you can get your dog to drink it, does the Nyla bone water additive do anything other than freshen breath? Also, what is this denta-c referenced in the water additive, breath spray, and foaming tartar remover?
Can the probiotics in kefir survive your dog’s stomach acid? I know the probiotics and yogurt can survive in humans, but the pH levels are different.
If digestive enzymes help dogs with pancreatic insufficiency, why can’t they help dogs with food sensitivities?
Even though the myth about collagen isn’t true, are there any benefits to giving a dog gelatin?
If liquid fish oil causes reduced shedding in my dog, is it really helping, or just masking the symptoms of an allergy?
Do dogs need sunscreen?
Where did the slim doggy App get caloric information for various exercises like swimming, when the only research that has ever been done involves dogs that were running? If they are using human caloric information, which won’t work because dogs metabolize food differently and pull more energy from fat, can they get in trouble for fraudulent marketing? Because there is no research, how are you supposed to know how many calories your dog is burning through exercise if you want to maintain the weight through more than just guesswork?
Art turmeric and mushroom extract beneficial to dogs?
Could you please write about the Slimdoggy app. It will be worth your time. I promise. The developers claim to know how many calories your dog burned during exercise when I can only find one study about that. If they are using human values to extrapolate how many calories your dog burns, that is fraudulent marketing. So basically, when you go to the app, you can put what activities your dog did like swimming, walking, and playing, and it will tell you how many calories your dog supposedly burned. So if actual veterinarians don’t know that information, how do the developers of this app no? Do they have some secret research that they are not sharing with the veterinary community? It is only $2.99 on the App Store. It wouldn’t hurt to at least check it out. I cannot get a hold of the developer and expressed my concerns A review q. that it could be fraudulent, but have gotten no response. What if dog owners are using this app to manage their dogs weight, and the app is based on completely in accurate information? People need to know.
There are a lot of apps like this for humans (I use several for running and other exercise), and they are notoriously inaccurate and inconsistent with each other. There are so many factors involved in the energy consumption during exercise, including sex, age, size, conditioning, other individual factors, environmental conditions, nutrition, etc., that it is impossible to get an accurate result solely from the general type of activity and the duration. My various apps often contradict each other even when they use algorithms that account for some of these factors and when I include heart rate monitoring.
Such apps can give a very crude ballpark, and they are probably most useful in showing us how few calories we burn during most activities. In fact, exercise contributes very little to weight loss, though it has lots of other important health benefits.
It seems quite unlikely that this app could have very accurate output, though I haven’t seen any data about it. And unfortunately, if people are using it to try and guide feeding for weight loss, it’s going to be far less effective than simply reducing calories in a stepwise fashion and monitoring weight.
Hello, I recently adopted two wonderful cats as my first real pets in life. My parents are allergic to everything and it wasn’t until this January that I got tested for allergies and discovered I’m allergic to nothing! So I got me some furballs and am exploring the cat subculture. I recently attended http://www.catcampnyc.com/speakers/ and discovered Lil Bub http://lilbub.com/about who has an extraordinary combination of maladies. It’s unfortunate that her owner hasn’t really found effective treatments for her, and has been forced to explore bogus options from local “wizards”, old hippies in rural Indiana where they live. Of particular interest is their use of “Assisi Loop, which uses Pulsed Electromagnetic Field Therapy.” But really, there’s so much that Lil Bub has to offer a Skeptical Vet that a whole series could be done on her! Please?? I want her to both get real and effective treatment and not have her celebrity used to peddle pseudoscience. Thanks!!
Nzymes were a life saver for my dogs. One, brothers, got a horrible skin rash every summer. We spent so much money at the vet and nothing worked, until Nzymes. I put them on it and he never got that rash again. While I lost him in 2013 to an inoperable chest tumor..his brother will be 14 this year and is healthy as ever. I swear by Nzymes; snake oil it IS NOT!!
Why Anecdotes Can’t Be Trusted
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