Assisi Calmer Canine-What’s the Evidence for PEMF Treatment of Separation Anxiety?

I haver written about pulsed-electromagnetic field devices (PEMF) a couple of times before (12). In my most recent review, I concluded:

Despite the fact that there has been interest in the potential medical applications of electricity for over 150 years, and serious scientific research investigating PEMF has been going on for over 50 years, there is surprisingly little robust evidence showing meaningful clinical benefits…PEMF devices are widely used, and this creates the impression that they have been solidly validated, but the reality is more ambiguous…There are very few clinical trials of PEMF in [veterinary] patients. The studies that have been published have not found consistent and convincing evidence of clinically meaningful benefits…The marketing claims of PEMF manufacturers and the excitement of proponents far exceed the strength of the available scientific evidence.

Unfortunately, the lack of evidence is seldom a barrier to aggressive marketing of therapies in veterinary medicine, and this is certainly true for PEMF. What is perhaps more frustrating, is that companies often support or produce small studies with significant limitations as evidence to promote particular uses. These studies are rarely followed, as they should be, by larger, better trials that could be used to justify actual clinical use. 

This certainly appears to be the case for the most well-known veterinary PEMF device, the Assissi Loop. Rather than following up the tentative studies I reviewed for pain, the company has decided to generate yet more weak evidence to justify marketing their device for yet another indication, this time separation anxiety. Their marketing materials are a classic example of claims that go far beyond anything justified by the actual scientific evidence:

The solution” is bad enough, but there had better be some pretty solid clinical research to justify “returns the anxious brain to a more balanced emotional state with long-lasting effects” and “proven to work alone without other treatments or training!” I can’t wait to see the large, robust, long-term clinical trial that shows the Assissi Loop is ready to replace all other separation anxiety therapies and vanquish the disease for ever! So where is it? What? There is no such study?

To call what the company offers as evidence for these dramatic claims underwhelming would be a dramatic understatement. An open-label study lasting six weeks in nine dogs. That’s it! No placebo control, no blinding, no peer-reviewed publication (only a conference report), and a lead investigator who also happens to be the Chief Business Officer of the company selling the product. A pilot trial like this is laden with uncontrolled bias and error, and while it might be enough to justify a real controlled study, it is not even close to sufficient evidence to support the wild marketing claims made for the product. 

I would be thrilled to see a treatment with no detectable adverse effects that could improve or even cure separation anxiety in the vast majority of dogs with 15 minutes of treatment twice a day for six weeks. That would be a miracle, and I would be glad to see it. However, the evidence threshold for miracles in medicine is pretty high, and this study isn’t even close to that threshold. It seems to me inappropriate to make such dramatic promises based on such thin evidence, and it would be more useful for companies such as this to put their resources into supporting rigorous, independent testing of existing claims rather than looking for new markets to create with still more small, limited “pilot” trials.

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3 Responses to Assisi Calmer Canine-What’s the Evidence for PEMF Treatment of Separation Anxiety?

  1. bionaze says:

    I can’t wait to have enough money to buy this and try it with my box, Pax. Nothing else is really working for him. 🙁

  2. Rich says:

    The AKC FAMILYDOG March/April 2020 issue has a glowing write up using the Assisi Calmer CSA on pages 35-37. CAN’T LEAVE HOME WITHOUT IT A new device helps dogs and their humans weather separation anxiety. by Stacey Freed Digital version is available here:

    Margaret Gruen, a veterinary behaviorist and assistant professor at North Carolina State University in Raleight is involved with a study on separation anxiety and the new device, the Calmer Canine. Claims “a recent Harvard University study used PEMF signals to help humans with depression and anxiety. It is FDA-approved for use in humans with pain.” In a section titled “Successful Trials”, seems to only refer to an earlier trial a NCSU using 10 dogs. “Now more than 50 dogs have been studied.” They cite one case where a dog went from “855 time in one hour and after a month of treatment, he went to zero barks”. Not very clear reporting on this otherwise. I wonder if they had a control group with the device turned off? *sigh*

  3. v.t. says:

    Wouldn’t this fall under FDA-CVM “medical devices”? (unapproved, subject to warning letters and subsequent action)

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