Nope, Glucosamine and Chondroitin Still Don’t Work in Humans

Just one more nail in the lid that’s never coming off the coffin of glucosamine and chondroitin. Despite the ubiquity of these supplements and the innumerable testimonials for their benefits in people and in pets, the research continues to accumulate that they are nothing more than a placebo when it comes to treating arthritis pain. A new meta-analysis in the British Medical Journal looking at 10 trials with over 3800 patients followed for up to 2 years found no clinically significant affect of glucosamine or chondroitin supplementation on pain scores of joint width (a measure on cartilage degradation). Not surprisingly, industry-funded trials tended to have more positive results than independently-funded trials.

Of course, people will argue that this is not directly relevant to the use of these supplements in dogs and cats, and we should not discount their potential value in these species without similar high-quality studies. There is some truth to this, but given the limitations in resources and technical difficulties of veterinary research, the absence of any plausible reason to think that these products might perform better in animals than in humans, and the uninspiring results of the non-industry funded veterinary research on glucosamine and chondroitin so far, it would seem to be placing our bets on the long shot to put much more of our limited resources into studying these therapies.

Then again, it’s hard to find a dog, cat, or horse that isn’t already on glucosamine and chondroitin, so a cynic might ask whether the evidence really matters or not anyway. Luckily, I am an inexhaustible well of optimism about human nature, so I would never be so cynical. 🙂

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3 Responses to Nope, Glucosamine and Chondroitin Still Don’t Work in Humans

  1. Alison says:

    I get the impression that a lot of horses owned by professional riders are on glucosamine and chondroitin supplements, but because I’m a cynic I always assume that this is largely because they get free supplies in return for endorsing the products on the manufacters’ adverts. Or because they are tax-deductible expenses. In the UK these supplements are preposterously expensive, all the more so if, as seems likely, they don’t actually work. Most of the ordinary horse owners I know use alternatives such as devil’s claw, or herbs such as meadowsweet, or cider vinegar, or cod-liver oil, which probably don’t work either but which are considerably cheaper.

    Most horses are on some sort of feed supplement. I’ve just seen the results of a survey of over 1000 amateur riders. 85% said their horses got at least one supplement; 27% gave their horses more than four. That’s every day, in addition to normal feeds.

  2. Pingback: Glucosamine – going the way of echinacea (and with just as many hanging on to their belief – in spite of all evidence) « Gilgablog

  3. Pingback: Veterinary Arthritis Treatments | The SkeptVet

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