More Hypocritical Nonsense about “Healthcare Choice”

Readers of this blog will be familiar with Dr. Shawn Messonier and his style of promoting alternative veterinary medicine by lying about scientific medicine and veterinarians who practice it (e.g. Here, Here, and Here). The latest example of this behavior is also a fine example of the bogus CAM marketing approach known as “healthcare choice.” I written about this strategy before, but in brief it is the claim that any argument against alternative methods, and certainly any attempt at regulation that requires proof of safety and efficacy before marketing a medical intervention, is an unjust suppression of people’s right to choose their own form of health care. Usually the argument is paired with accusations or implications that anyone who questions whether CAM works or is safe is only interested in protecting their own income.

Dr. Shawn makes this argument in its classic form in a recent blog post.

“As an integrative, naturopathic doctor, my practice is all about choice. While I hope I can convince my pet owning clients that using natural therapies whenever possible is the better, safer, usually less expensive, and healthier way to go, ultimately the choice of therapy chosen is up to the client.

If the client chooses a more conventional drug therapy, that’s her choice and I will never interfere with that choice…

It seems to me however that skeptics who rally against natural therapies don’t want their patients or clients to have this choice.
For many of these skeptical doctors, it’s “their way or the highway!”

They consistently try to talk patients out of a more natural approach to healthcare, all the while demeaning and insulting this choice, as if this choice is invalid or irrational…

The only answer I can come to after researching this question is this: economics.

If a doctor only offers one choice, in this case conventional drug or surgical therapy, and you choose a more natural approach, that means you will have to find another doctor. Your current doctor loses your business, and your choice punishes his pocket book. He won’t like that and will do anything to keep you as a patient.”

This argument is, of course, merely a cynical attempt to convince pet owners to choose Dr. Shawn’s methods by hypocritically claiming to offer more “choice,” which sounds better than admitting he has nothing but his word to offer as proof that his alternative methods actually are better for his patients. He criticizes conventional veterinarians for trying to talk clients out of using unsupported or outright quack therapies yet he admits to trying to convince his clients these therapies are better than scientific medicine, to which end he has many books, a radio program, and of course his web site, all of which are ways he makes his living. The argument is blatantly hypocritical on the face of it.

On his website, the good doctor discourages vaccination; claims commercial diets are full of toxins that lead to cancer; refers to pets taking conventional drugs as “pharmaceutical cripples” and encourages pet owners to “say NO to drugs,” and in many other ways discourages conventional medical therapies. Granted, he also makes use of many of the treatments provided by sound scientific medicine, and his practice philosophy seems to consist mostly of adding the unproven and the opinion-based on top of conventional medicine, but this is not about giving pet owners more choice, it is about pushing his own beliefs and opinions and then slandering anyone who challenges him to back those up with real evidence. If trying to convince clients about what one believes to be the true facts regarding a particular treatment is “interfering” with teir choice, than Dr. Messonier is as guilty of this as anyone.

CAM practitioners often claim to promote choice while actively claiming scientific medicine is mistaken and causes great harm. And it is not unusual to find statements such as the following from self-professed “holistic” veterinarians:

“Use of Other Modalities and Medications

The treatment program that we use is not compatible with the simultaneous use of conventional drugs such as antibiotics, corticosteroids, thyroid hormones, etc. As the cases progresses, you may be guided in the gradual discontinuance of some or all these medications. This is necessary so that our methods can take full effect. In addition, if other symptoms appear during treatment (or older, previous conditions return) you will be expected to contact us for appropriate response rather than use drugs that you may have used before. The reappearance of older problems can be a very good sign that the body is beginning to heal and this is usually a very delicate and important time. The use of conventional medications and treatments might make this healing impossible!”

However, the “health care choice” argument is wrong in many ways besides merely being hypocritical. It evades the underlying issue of what the choices being offered actually are. If a client is told that an unproven treatment is safe and effective and that conventional preventative or treatment interventions are toxic and harmful not helpful, then they are being deceived, intentionally or by the genuine mistaken beliefs of the practitioner. A choice to rely on placebos or therapies that don’t work and may very well do harm based on an “educational” harangue is not a true informed choice in an meaningful sense. The whole point of evidence-based medicine is to support our recommendations with objective scientific research, not merely our own biases and opinions. And the motivation behind practicing evidence-based medicine is better patient care, not simply making money.

Alternative therapies have not earned any special exemption from rigorous objective testing or criticism. They should be judged, as scientific medicine is judged, on their merits, not on the strength of the faith their proponents have in them. Viewing the implausible skeptically and asking for evidence rather than taking Dr. Shawn’s or anyone else word for the safety and efficacy of alternative methods is the right way to protect the well-being of our patients, an trying to label it an unfair restriction of consumer choice motivated by greed is simply another example of the unprofessional, hypocritical, and vapid marketing strategies many CAM proponents have to rely on absent the real convincing evidence they fail to provide.

Dr. Shawn has the zeal of a true believer, and the inability to consider the possibility he might be wrong. Claims like his of offering more freedom of choice than conventional veterinarians are simply a marketing strategy based on caricaturing and slandering veterinarians who practice science-based medicine and evading the challenge of backing up their medical practices with something more convincing than their own opinion and experience. Such language is unfortunately often effective in a society that sees choice as automatically a virtue and that likes simple, personalized arguments rather than complex, nuanced, and fact-based ones. We who adhere to the standards of evidence-based medicine are at the disadvantage of not being able to make any claim we like regardless of whether we can support it, and those of us who believe in challenging ideas and arguments rather than people and their motives are at a disadvantage in such debates as well. Rarely do you see too sober, polite, and well-informed adversaries arguing complex scientific issues on daytime television, since it is far less compelling to watch than vapid appeals to emotion like the “healthcare choice” argument. More’s the pity.

Posted in General, Law, Regulation, and Politics | 14 Comments

Risks of Herbs and Supplements Finally Getting Some Attention

Some of the most popular forms of alternative medicine are the myriad herbs and “dietary supplements” (a faux category created by the 1994 Dietary Supplement Health and Education [DSHEA] act to allow marketing of unproven drugs without regulatory oversight). These nostrums are potentially more useful than outright quackery like homeopathy or “energy medicine” because they contain actual physiologically active chemicals. Unfortunately, that means these are also the most likely for of CAM to cause direct harm.

There have been numerous examples of this kind of harm in the past. Kidney failure caused aristolochic acid in traditional Chinese medicines, lead poisoning from contaminated Ayurvedic and Chinese preparations, and deaths from ephedra-containing supplements such as ma huang are among the most dramatic and well-publicized examples. Below is an extensive list of references regarding these and other such examples.

Despite this, the perception that such preparations are “safe and natural” still seems widespread, and it seems difficult to disabuse people of this notion. However, I am encouraged by a number of recent indications that the risks associated with untested and unregulated supplement use may be getting more attention. I recently wrote about an article looking at the association of herbal therapy with poorer compliance and quality of life in asthma patients.

Another article on the subject that recently caught my attention was entitled Dietary Supplement Polypharmacy: An Unrecognized Public Health Problem?, published in eCAM. The article is essentially a series of anecdotes, so of course it proves nothing about the overall impact of herbal remedies. However, the theme that emerges from the cases reported strikes me as key to understanding the risks of such treatments. The cases almost all involved people who took herbal preparations for more psychological than medical or rational reasons. They generally took a variety of supplements, often with no systematic dosing or schedule or even any understanding of what they were taking or what the intended effects or possible side effects were. This is only possible because these people accepted the baseless notion that somehow because they were “natural” these preparations could be expected to have beneficial effects without any risk, any dose/response relationship, or any of the usual limitations know to affect pharmaceuticals.

Ironically, the people discussed in the article also commonly reported turning to herbs and supplements because of fears of the side effects of conventional medical therapies. This is similar to the attitude reported in the study of asthma patients. Clearly, any therapy that has measurable effects is going to be tinkering with a complex and massively interconnected system, and this makes it highly likely that unanticipated or undesirable effects will occur as well. In scientific medicine, it is understood that all therapeutic decisions require a cost/benefit analysis, and that while it is appropriate to avoid unnecessary interventions that might do more harm than good, there are clearly many circumstances in which the risks of a treatment are far outweighed by the potential benefit. CAM advocates and users seem to have the notion that these rules only apply to conventional medicine, and they tend to have an exaggerated awareness of risks while taking the benefits for granted. They then fall prey to the irrational and demonstrably false notion that CAM therapies are exempt from the rules of pharmacology and physiology that constrain scientific medicine and that they can somehow get something for nothing–benefits without risk. This is a dangerous notion which must be debunked so that the true potential of herbal medicines can be developed in a rational and scientific way and unnecessary risks be avoided.

Finally, the cases illustrate the sense many CAM users have of not being in control of their medical care when dealing with conventional, scientific medicine. Being able to change their diet, take supplements or herbal remedies guided by their own internal sense of how they are responding, and so on gives them a feeling of having some control over their bodies and their care. This is a challenging psychological issue. Scientific medicine has rightly moved away from the paternalistic model and acknowledges that patients have the ultimate right to make decisions about their own care. However, it is also an undeniable fact that health care have factual knowledge and a overall perspective that make their assessments and decisions about specific interventions generally more reliable than those of lay people with a personal and intense emotional investment in their or their pets health.

Somehow, scientific medical providers need to do a better job of dealing with the psychological aspects of disease in their patients or, in the veterinary domain, their patients’ owners. We must understand and manage the normal psychological factors that lead people into use of unproven or bogus therapies while maintaining a solidly scientific and evidence-based standard for the medicine we employ. And we must do all of this within the limitations of time and resources under which we operate. A significant challenge indeed.

Another article I ran across recently that bears of the dangers of herbal medicine use is A review of the potential forensic significance of traditional herbal medicines in the Journal of Forensic Sciences (Byard RW. 2010:55(1);89-92). This is a nice summary of some of the specific dangers of unregulated and unscientifically used herbal preparations, including direct toxicity, heavy metal poising, adulteration with toxins, interaction effects of multiple active compounds taken together, and interactions with conventional medicines. These risks are exacerbated by the facts that many users of herbal remedies don’t tell their doctors what they are taking (or they may not know themselves), most doctors know little about the possible risks of such remedies, and there is no meaningful regulatory control over the preparation or marketing of these products.

On this last point, a revision to DSHEA has been proposed in the Senate by Tom McCain (R-AZ) and Byron Dorgan (R-ND). While not perfect, this bill would improve the FDA’s ability to monitor dietary supplements and other currently under-regulated supplements and to force removal of these from sale if there is evidence of harm. Given the power of the supplement lobby and their biggest legislative boosters, Tom Harkin (D-IA) and Orin hatch (R-UT), and the general anti-regulation mood of the country, I am not overly optimistic this will become law, but I am encouraged at least that mainstream political figures are at least willing to talk about the inadequacy of consumer protections in the area of herbs and supplements, and this alone may raise awareness of this underappreciated risk.
Coon JT, Ernst E. Panax ginseng: A Systematic Review of Adverse Effects and Drug Interactions. Drug Saf 2002;25(5):323-44 Drug Saf 2002;25(5):323-44

Cupp MJ  Herbal remedies: adverse effects and drug interactions. Am Fam Physician 1999 Mar 1;59(5):1239-45

Debelle FD, Vanherweghem JL, Nortier JL. Aristolochic acid nephropathy: a worldwide problem. Kidney Int. 2008 Jul;74(2):158-69. Epub 2008 Apr 16.

Emery DP, Corban JG  Camphor toxicity. J Paediatr Child Health 1999 Feb;35(1):105-6

Ernst E Adverse effects of herbal drugs in dermatology. Br J Dermatol 2000 Nov;143(5):923-

Fugh-Berman A Herb-drug interactions. Lancet 2000 Jan 8;355(9198):134-8

Huang WF, Wen KC, Hsiao ML. Adulteration by synthetic therapeutic substances of traditional Chinese medicines in Taiwan. J Clin Pharmacol. 1997 Apr;37(4):344-50

Lai MN, Lai JN, Chen PC, Tseng WL, Chen YY, Hwang JS, Wang JD. Increased risks of chronic kidney disease associated with prescribed Chinese herbal products suspected to contain aristolochic acid. Nephrology (Carlton). 2009 Apr;14(2):227-34.

Lawrence JD.  Potentiation of warfarin by dong quai. Page RL 2nd, Pharmacotherapy 1999 Jul;19(7):870-6

Means C.  Selected herbal hazards. Vet Clin North Am Small Anim Pract 2002 Mar;32(2):367-82

Norred CL, Finlayson CA Hemorrhage after the preoperative use of complementary and alternative medicines. AANA J 2000 Jun;68(3):217-20

O’Connor A, Horsley CA. Yates, KM “Herbal Ecstasy”: a case series of adverse reactions.  N Z Med J 2000 Jul 28;113(1114):315-7

Pittler MH. Ernst, E Risks associated with herbal medicinal products. Wien Med Wochenschr 2002;152(7-8):183-9

Poppenga RH. Risks associated with the use of herbs and other dietary supplements. Vet Clin North Am Equine Pract. 2001 Dec;17(3):455-77, vi-vii

Pies R  Adverse neuropsychiatric reactions to herbal and over-the-counter “antidepressants”. J Clin Psychiatry 2000 Nov;61(11):815-20

Prakash S, Hernandez GT, Dujaili I, Bhalla V. Lead poisoning from an Ayurvedic herbal medicine in a patient with chronic kidney disease. Nat Rev Nephrol. 2009 May;5(5):297-300.

Raman P, Patino LC, Nair MG. Evaluation of metal and microbial contamination in botanical supplements. J Agric Food Chem. 2004 Dec 29;52(26):7822-7

Ruschitzka F, Meier PJ, Turina M, Luscher TF, Noll G  Acute heart transplant rejection due to Saint John’s wort. Lancet 2000 Feb 12;355(9203):548-9

Saper RB, Phillips RS, Sehgal A, Khouri N, Davis RB, Paquin J, Thuppil V, Kales SN. Lead, mercury, and arsenic in US- and Indian-manufactured Ayurvedic medicines sold via the Internet. JAMA. 2008 Aug 27;300(8):915-23.

Shad JA, Chinn CG, Brann OS Acute hepatitis after ingestion of herbs. South Med J 1999 Nov;92(11):1095-7

Smolinske SC J Am Med Womens Assoc 1999 Fall;54(4):191-2 Dietary supplement-drug interactions.

Yang HY, Wang JD, Lo TC, Chen PC. Increased mortality risk for cancers of the kidney and other urinary organs among Chinese herbalists. J Epidemiol. 2009;19(1):17-23. Epub 2009 Jan 22.

Zhang SY, Robertson D. A study of tea tree oil ototoxicity. Audiol Neurootol 2000 Mar-Apr;5(2):64-8

Kidney failure from aristolochia in TCM herbals preparations.

Lead, mercury and arsenic in herbal preparations.

Lead in TCM preparations.

Lead in ayurvedic preparations.

Lead in herbal preparations.

Tea Tree Oil Can be toxic to cats.

Toxic metals in Brazilian herbal preparations.

Contamination of herbal products with undisclosed pharmaceuticals.Widespread contamination of supplements with undisclosed toxins and parmaceuticals

Posted in Herbs and Supplements | 12 Comments

Use of herbals associated with lower quality of life in asthma patients

Proponents of CAM often claim that one major advantage to their methods is the absence of side effects seen with conventional medical treatments. This makes little sense since there is no “free lunch” in physiology, and an intervention that affects one part of the system is going to have effects on other parts as well. Those practitioners who claim a “holistic” approach ought to realize this. If the treatment has absolutely no side effects, it’s probably because it isn’t doing anything at all.

And there is plenty of evidence that some CAM treatments can be harmful. While certain therapies, like homeopathy or reiki, may have little direct harm, they can still discourage patients from seeking and complying with more effective, evidence-based therapies. And the very CAM therapies most likely to turn out to have real benefits, herbal preparations, are also the most likely to cause unintended harmful effects, which is why they need to be properly studied before being used in practice.

A recent article in the Annals of Allergy, Asthma and Immunology surveyed primarily low-income inner city patients with chronic asthma to identify use of herbal treatments and any apparent association with how well their disease was controlled. What they found was that a moderate number of patients (25%) used herbal remedies for their asthma. Only about 39% of these people told their doctors about the use or herbal remedies, which raises the concern for unanticipated drug interactions. And about 20% of the herbal medicine users (about 5% of the total number of patients) used herbal treatments in place of their prescribed therapies.

Not surprisingly, the folks who used herbal preparations had a lower quality of life score and were significantly less likely to be complaint with their prescribed treatment regime than those patients who did not use herbal products. The authors also reported a trend towards poorer asthma control scores among herbal users. but this did not achieve statistical significance so it may not be a real finding.

The authors were careful to point out, correctly, that the association cannot identify a causal connection between quality of life and herbal remedy use. The poorer compliance with prescribed therapy can reasonably be suspected to be the causal factor, but it is impossible from this study to rule out a direct harmful effect from the herbal remedies or the possibility that people are seeking these remedies because they are not having an acceptable response to conventional therapy and that their poor compliance came after turning towards the CAM therapy.

However, there was also a correlation between use of herbal treatments and certain beliefs about conventional therapy, including concern about possible side effects and difficulty in following the prescribed treatment regime. This suggests that anxiety about the conventional treatment might be associated with susceptibility to the promises of safe and easy relief often used to market herbal therapies. This paper illustrates the dangers of such marketing strategies, which play into patient concerns which may be perfectly legitimate but which then offer alternatives which do not provide the relief the patient is seeking.

Posted in Herbs and Supplements | 8 Comments

We can’t prove it, but….Faith-based medicine and special pleading

CAM proponents often engage in the rhetorical fallacy known as special pleading. Wikipedia’s definition of this is adequate: “a form of spurious argumentation where a position in a dispute introduces favorable details or excludes unfavorable details by alleging a need to apply additional considerations without proper criticism of these considerations themselves. Essentially, this involves someone attempting to cite something as an exemption to a generally accepted rule, principle, etc. without justifying the exemption.”

Because many forms of CAM, such as homeopathy and various “energy” and “mind-body” therapies are based on principles inconsistent with established scientific knowledge, their advocates sometimes have to try and find ways to justify why these methods should be taken seriously despite this major weakness. They frequently argue that their methods rely on principles science does not yet, or perhaps cannot, understand. They argue that, despite the incontrovertible success in the last few hundred years of established methods of scientific investigation in figuring out and manipulating phenomena in the real world, these methods are culturally defined (i.e. “Western”) and only apply to their cultural of origin, or that they are incapable of dealing with new kind of phenomena.

These arguments seem pretty weak in the face of historical reality, but there is of course always a chance that a given “paradigm shift” or “revolutionary” new principle of biology, medicine, or physics has been discovered that turns all we know out the door.  However, this is an extraordinary claim, and it cannot be defended simply by pointing to a few anecdotes, one’s personal experience, or the ultimate foundation I believe it really rests on, faith. The whole reason we even have a category of medicine called “alternative” (or as I prefer to call it, “faith-based medicine”) is because people believe things they cannot convincingly demonstrate to those who do not share their faith or their trust in personal experience.

In 2008, there was a symposium held at the UCLA Center for East West Medicine (note the postmodernist bias that all knowledge is culturally relative even in the very name of the organization) and reported in eCAM. The purpose of the symposium was, as always, to try and convince mainstream medicine and the public of the scientific legitimacy of CAM.

“Its purpose was to address the finding by the National Center for Complementary and Alternative Medicine (NCCAM) that IRB’s may be unfamiliar and/or uncomfortable with unconventional medical modalities thus apt to disapprove studies of those modalities. The hope was to better this state of affairs by familiarizing the audience with some of the major controversies surrounding CAIM research and its regulation.”

NCCAM has been widely criticized for being a tool of the CAM political lobby and of wasting taxpayer money trying to validate implausible therapies only because they are favored by powerful politicians or well-funded lobbies. This criticism, and questions about the scientific legitimacy and ethics of NCCAM-funded research was raised by critics at the UCLA symposium, and the responses of CAM advocates are enlightening in that they demonstrate the special pleading CAM requires because it cannot meet the evidentiary standards of scientific medicine.

According to the eCAM article, “Dr Ary Goldberger, Director of the Margret & H. A. Rey Institute for Nonlinear Dynamics in Medicine at Boston’s Beth Israel Deaconess Medical Center and Professor of Medicine at Harvard Medical School….suggested that conservatism in science extends to the underlying approach to physiological systems, often wrongly privileging homeostasis (‘constancy as the wisdom of the body’) over complex adaptability, multi-scale dynamics and emergent properties. In as much as they are non-linear, non-stationary, non-additive and show time irreversibility, however, complex systems may be inaccessible to conventional analytic techniques, according to the speaker. Dr Goldberger left the impression that he believes both investigators and NIH Centers in general ought to be more open to novel but rigorous research designs and methodology.”

So here’s the claim that because CAM methods don’t seem to get validated by conventional scientific investigations, the flaw must be not with those methods but with the very nature of science. We need to invent new ways of studying nature, despite the wild success of our current approach, because the methods he favors don’t get validated the way we do things now. Again, paradigm shifts do happen, but they are rare, and the vast majority of revolutions proclaimed by outsiders in science are nothing more than desperate attempts to defend failed ideas.

Next, Distinguished Professor Edwin Cooper (Editor in Chief, Evidence Based Complementary and Alternative Medicine) “raised questions about what passes for good research methodology, asking whether studying ancient, whole systems of medicine using Western, reductionistic techniques doesn’t strip them of essential features.”

Here again is the postmodernist notion that truth is culturally relative, and that science somehow only applies to ideas that originated in the culture that most directly contributed to the creation of modern scientific methods. This is blatantly ridiculous, as any Chinese or Indian or other “Eastern” patient benefiting from modern scientific medicine could tell you. Our physiology doesn’t care where we live or what language we speak, physics doesn’t work differently on different continents, and while values depend heavily on culture, the truth about how our bodies work doesn’t. Millennia of traditional folk methods in India or China or anywhere else failed to eradicate infectious diseases like polio, lower infant mortality, raise life average expectancy, or otherwise improve human health and well-being to anything like the extent “Western” science has in only a few hundred years. The notion that other cultures have other medical realities is at best a sincere but weak defense of implausible or outright failed ideas based on the inappropriate translation of cultural relativism to the scientific domain. At worst, it is simply old-fashioned orientalism with the patina of scientific “open-mindedness.”

My favorite comment, though, comes from Professor-in-Residence Mark Cohen. First continuing the special pleading approach, he “expressed the view that current research tools may be inadequate for measuring the effects of some CAIM treatments.” Yeah, well prove it. But he then went on to all but admit that CAM is a faith-based belief system much more like religion than science: “he noted that taxpayers already support faith-based initiatives and questioned whether conventional science has a ‘special entitlement’ to public funds, given that orientation.” Here he is saying that because a large number of Americans accept giving government money to religious organizations for performing services previously considered the responsibility of a secular government, we should similarly support giving taxpayer dollars to study CAM rather pretending conventional science should have a special claim to research money just because it is a proven and effective approach and CAM is mostly a hodgepodge of vitalism, folk traditions, and stuff outright made up by unappreciated lone genius or know charlatans. Our faith, our belief alone should be sufficient to justify it. It isn’t possible to be much clearer about the philosophy behind alternative medicine than that.

Posted in General | 2 Comments

Oximunol–The latest in marketing masquerading as science.

A couple of  “news” articles, which were essentially truncated but often verbatim reprints of a company press release, appeared today about a clinical trial looking at a mysterious new veterinary product with grand but vague claims. Naturally, this caught my attention.  🙂

The Chemaphor company announced “it has completed its first clinical trial to evaluate the efficacy of an oral Oximunol supplement in promoting overall health and well-being of companion canines.” The only details of this trial were that it was a “blinded, randomized clinical trial involving forty six dogs recruited from the public. The animals were randomly assigned to receive either the Oximunol supplement (0.5 mg/kg body weight) or a placebo once daily over a period of six months. The Oximunol supplement’s potential benefit to canine wellness was assessed by analyzing owner responses to standardized questions regarding the health status of their pets before and after the supplement period” The press release claims, “A full report of the study is being prepared for submission for publication in a peer-reviewed journal.”

So what is Oximunol?  It is described as “a proprietary mixture containing compounds found naturally in the plant world in minute amounts as oxidized derivatives of carotenoids. The supplement is obtained via the spontaneous, full oxidation of beta-carotene.”

There are a number of red flags here right from the start. Announcing the results of a “clinical trial,” especially one conducted in house by a company trying to launch a new product, in a press release prior to publication in a legitimate journal is a marketing ploy that is rarely consistent with good science. And while it is impossible to judge the merits of the study without having it properly vetted and published, I am skeptical of a trial that starts with the hypothesis of the treatment “promoting overall health and well-being” and that reports as, presumably, its best and most newsworthy findings “improvement in coat quality and reduction of shedding[and]….a tendency to increased enjoyment of walks” as judges by subjective owner assessment. Vague and lofty goals of health promotion and vague, subjective measures of success do not inspire confidence in the reliable scientific evidence for a treatment.

The company web site indicates they are producing and preparing to market a couple products derived from oxidation of beta carotene, and they make a number of claims about these molecules:

“OxBC is a premium product embodying the untapped potential of the many non-vitamin A carotenoid oxidation compounds we believe are the true agents responsible for the various non-vitamin A activities of carotenoids.”

OxBC possesses a wide range of biological properties that are exerted non-toxically. These include:
1. Inhibition of proliferation of cancerous cells grown in vitro (5-30 micromolar concentration);
2. Effective inhibition of growth of experimental tumours implanted in mice, (10-30 mg/kg body weight injected intraperitoneally, dose frequency every 1-3 days);
3. Promotion of cellular differentiation in vitro (concentrations roughly same as for item 1);
4. Non toxic bioactivity, in vitro and in vivo (e.g., mice, multiple injections; 150 mg OxBC/kg body weight);
5. Enhancement of intercellular gap junctional communication in vitro;
6. Induction of Phase 2 enzymes in vitro (shown for at least one component) implies cancer chemoprevention activity;
7. Promotion of growth and feed conversion in food production animals.”

OCL-1 is Chemaphors’ primary cancer drug candidate for the following reasons:
• Non-toxic inhibition of growth in mice of tumours derived from human cell lines
• Wide therapeutic range of activity
• Available orally
• Rapid tissue distribution and penetration predicted by low molecular weight (<150 Da) and fat-soluble nature
• Antimetastatic activity
• Chemopreventive anticancer activity
• Novel – although a carotenoid oxidation product, it is virtually an unknown compound
• No known reports of biological activity of any kind prior to Chemaphor’s studies
• Unusual chemical structure with potential to elaborate into a distinct chemical class with a spectrum of biological activities
• Non-classical, non-toxic mechanism of anti-tumour action, e.g. enhanced gap junction intercellular communication
• Low manufacturing cost based on simplicity of chemical structure.”

No references are cited to support any of these claims. A quick PubMed search finds some references to in vitro studies of some similar compounds, but no clinical trial evidence of significant benefit in humans, and no studies of non-retinoid carotenoids at all in dogs. This is not to say the molecules couldn’t have beneficial effects as cancer preventatives or therapeutics or in some other application, only that the company is following the all too common and unfortunate path of building hype and marketing products without adequate evidence of safety and efficacy. As I have discussed before, this is a tried and true strategy for supplement manufacturers, trying to take preliminary hints of utility for a product and use them to support sales before definitive evidence can disprove them. It may make economic sense, but it is scientifically and ethically indefensible.

And the promotional materials for Chemaphor make it very clear that the goal is to draw investors and their dollars. They are refreshingly open about the economic aspects of their agenda.

” Chemaphor is developing a set of major, business opportunities centred on the rich, non-pharmaceutical potential of the OxBC product….In comparison to drug development, each opportunity offers shorter product commercialization times by requiring much less development work and being subject to less restrictive and smaller regulatory hurdles. Yet each business activity addresses global market biotechnology segments with major, multi-million dollar revenues.”

Target market areas:
• Non-antibiotic feed additives for improving growth and feed conversion efficiency in production animals (e.g. poultry and swine)
• Nutraceuticals for companion animals
• Veterinary applications
• Skin care

Intended applications of products:
• Improving growth and feed conversion in swine and poultry
• General promotion and maintenance of good health in farm animals, dogs, horses and cats (companion animal nutraceuticals; feed additives)
• Control of diseases of aging (e.g., cancer) in companion animals (pet nutraceuticals)
• Anti-aging protection of skin, including protection against skin cancer (skin care and cosmetics, e.g., after exposure to sun)
• Amelioration of pre-existing skin conditions or prevention of recurrence of treated conditions (skin care and cosmetics)
• Maintaining healthy skin by providing broad, multi-level protection against various conditions (skin care and cosmetics)”

“In the area of pet nutraceuticals, Chemaphor’s goal is to obtain entry into this rapidly growing, lucrative market with OxBC as a health-maintenance, chronic disease protecting product. The companion animal market is attractive because there is an unmet need for the type of product OxBC represents, the market is large, and it is the fastest growing segment of the animal health market, at over 6% per year. This market also poses lower regulatory hurdles to entry.”

There is, of course, insufficient information to say with certainty whether or not this company’s products have any real medical value, but these promotional materials are a classic example of what I’ve come to call Big CAM. Contrary to the mythology promoted by CAM advocates, in which small providers make available free or cheap health care miracles despite the oppressive forces of “industrial medicine” to keep our pets sick for our own monetary well-being, the reality is that CAM products represent a lucrative market and CAM manufacturers, distributers, and providers are just as interested in making a living as anyone else. The classic Big CAM features of this marketing material are:

1. Aggressively touting the benefits of a product well before adequate evidence exists to support the claims made.

2. Vague and lofty claims of treatment for a wide range of conditions, from cancer to aging skin.

3. A clear interest in taking advantage of the inadequate regulatory oversight for “dietary supplements” and other products that can avoid FDA or USDA requirements for proof of safety and efficacy.

These features justify some serious skepticism about the company’s claims. Before profiting from the belief the company is actively seeking to create, that it’s products offer health benefits to companion animals, the company ought to be obliged, by ethics if not laws, to prove that the product is truly beneficial. I hold out little hope that the regulatory agencies will enforce such an obligation, and I await with interest further indications of whether or not the company will voluntarily do the right thing and refrain from profiting from its products until it can convincingly demonstrate they are helpful and safe.

Posted in Herbs and Supplements | 7 Comments

wooTAG–uh, I mean shooTAG–Pest Control Device

I recently received a tip about a pest control product for pets (and people) that has woo written all over it. Anaglyph over at Tetherd Cow has written about the shooTAG pest repellant device, and has posted a follow-up response to a comment from the company CEO. I have little to add to his comments.

The product promotional materials are entertaining to read if you like science fiction. They freely refer to mysterious “bioenergetic fields,” “resonances,” and, of course, “quantum physics.” They offer testimonials and fanciful pseudoscientific explanations for how the product, which seems from the description to amount to a little strip of magnetic tape like the one on the back of your credit card,  somehow interacts with mysterious energies from the pet and the earth to repel pests. What they don’t offer is anything resembling a plausible scientific rational or actual research evidence to suggest any of their claims are true.

Some examples:

shoo!TAG™ represents a paradigm shift in the pest management industry. shoo!TAG™ utilizes Nature’s energetic principles in combination with physics, quantum physics and advanced computer software technology. The key to shoo!TAG™ is the three dimensional electromagnetic field embedded in the magnetic strip.

shoo!TAG™ utilizes the power of the bio-energetic field which surrounds all living things to create a frequency barrier which repels targeted pests for up to four months.

shoo!TAG™‘s magnetic strip is encoded with beneficial frequencies and resonances and an electromagnetic charge bearing a polarized energy signature, which when introduced into the bio-energetic field of the wearer produces results. ”

As always, one must be suspicious of “paradigms shift” language, which basically says, “We’ve found something that contradicts all the know laws of established science and we know it works because we think it works.” Likewise, non-physicists claiming to explain unlikely mysteries by referring to quantum physics is a big red flag. Quantum phenomenon are weird, but they seem only to apply at the atomic level, not the macroscopic level of dogs and fleas, and the mathematics required to truly understand them, as opposed to the metaphors of popularized explanations, is beyond most of us. That makes it easy to refer to a mysterious process as due to “quantum physics,” but it’s just a bit of vacuous pseudoscientific gibberish designed to obscure the lack of a real mechanism of action.

The company web site also makes pretty strong claims of efficacy, which I would think would interest the federal government since such claims have to be backed up by actual scientific evidence or they constitute fraudulent advertising. Sadly, the government rarely has time to investigate and control such small-time mountebanks, and they usually just switch labels and IP addresses and continue selling their quackery.

The only part of the company materials that goes beyond entertaining nonsense to outright irresponsible BS is the frequent claims that if the product doesn’t seem to be working, one should blame not the product but the “toxic” medical treatments the pet may have previously received, such as steroid medication, vaccines, and validated pest control products. Apparently these have not only their know side effects but mysteriously perturb the undetectable energy fields of our pest I such a way as to render the quantum mechanical mechanism of the wooTag–uh, I mean shooTAG– ineffective.

” Please keep in mind that if an animal has recently had a surgery, vaccinations, steroid medication, or you have been using heavy poison products on them it will take longer for your animal to detox and strengthen its energy field. It is important to note that, because the tags work with your pet’s energy field, it is important that they are as healthy as possible. We have found that animals that are on or have recently taken steroid drugs, that have recently had surgery, or are old do not respond well to our products.”

Once again we see a company marketing unproven, and unlikely nonsense through fear and misinformation and rationalizing their own failure by trying to shift the blame to the animals, the owners, or the medical therapies previously given. Truly irresponsible, shameless profiteering at the expense of pet owner’s fears. The people who promote such should be, but apparently cannot be, ashamed.

Posted in Miscellaneous CAVM | 7 Comments

CAM Word Salad

I often find that rationalizations of alternative medicine are garbled and hard to follow, but I recently ran across a site promoting veterinary alt med that combines the usual fuzzy logic with an mechanical or straight-from-the-dictionary translation into English, with what I find to be entertaining results. The full text is below, but here are a few choice sample:

“If we take herbal supplements, have ever treated with colour with colour yourself to a veteran massage, or have visited a chiropractor to have which creak in your behind bound…”

Wow, I wonder if anyone has ever seen a chiropractor to have a “creak in your behind bound?” J

” Holistic practitioners cruise your dog’s finish well-being, not usually sold symptoms or conditions, to find a diagnosis or treatments which will work best.”

I’ve heard of a lot of weird CAM therapies, but never cruising your dog’s finish to find a diagnosis.

Here’s a description of acupuncture I hadn’t heard before.

” Acupuncture helps soothe flesh spasms, enlarge red blood circulation, as good as stimulates nerves. In addition, it helps a physique recover full of health suffering carry out hormones as good as alternative beneficial chemicals. Acupuncture points have been infrequently wild with electricity, heat, massage, or lasers, instead of needles.”

Chiropractic doesn’t fare much better in the hands of the translator.

” Chiropractors hold which misaligned vertebral column lessen a upsurge of impulses from a spinal connective hankie to a body’s muscles viscera as good as tissues, as good as have been a means of a little illnesses as good as disorders…”

By contrast, the description of homeopathy is downright reasonable.

” Homeopathic diagnosis is a key of substances which furnish clinical signs identical to those of a mildew being treated with colour with colour in to a body. The thought is to yield a substances in amounts tiny sufficient to be harmless, nonetheless vast sufficient to inspire a physique to rise a antidote reply to a disease.”

And finally, this shining beacon of hope for the future of veterinary medicine.

“There is a fast flourishing seductiveness in holistic as good as interrelated approaches to veterinary medicine. As investigate progresses, scientists have been guidance not usually what works, though how it works, as good as stability to urge a lives of a doggie companions.”

If we take herbal supplements, have ever treated with colour with colour yourself to a veteran massage, or have visited a chiropractor to have which creak in your behind bound – we have an bargain of a benefits of pick medicine. And as some-more people comprehend a benefits for themselves, they take a judicious subsequent step of acid for pick illness therapies for their dogs.

What is interrelated medicine?
The tenure interrelated disinfectant is mostly used interchangeably with holistic medicine. Complementary disinfectant provides “non-conventional” treatments for a accumulation of ailments, for both humans as good as their dog companions. More as good as some-more veterinarians as good as house pet owners have been embracing a little of these brand new techniques as good as treatments.

Holistic disinfectant is a multiple of required veterinary disinfectant with a single or some-more interrelated therapies. Holistic practitioners cruise your dog’s finish well-being, not usually sold symptoms or conditions, to find a diagnosis or treatments which will work best. A holistic proceed to your dog’s complaint will customarily infer to be beneficial. Ongoing investigate in to a accumulation of veterinary therapies, both required as good as complementary, has done a noted alleviation in a peculiarity of caring a dogs receive.

When we have been acid for someone to perform these treatments, have sure he or she has been prepared in which sold recovering discipline. Get a mention from your unchanging veterinarian if we have to find someone else to yield your dog as good as have sure which your unchanging veterinarian receives finish as good as timely reports upon your dog’s progress. This ensures a most appropriate probable caring for your dog.

Some of a some-more usual interrelated recovering therapies right away accessible have been listed below.

Complementary therapies:
Acupuncture

The Chinese have used pain-killer for some-more than 3,000 years. They insert needles in to specific points upon a physique which they hold have been located along pathways analogous to opposite viscera of a body. Acupuncture helps soothe flesh spasms, enlarge red blood circulation, as good as stimulates nerves. In addition, it helps a physique recover full of health suffering carry out hormones as good as alternative beneficial chemicals. Acupuncture points have been infrequently wild with electricity, heat, massage, or lasers, instead of needles.

Acupuncture has proven to assistance soothe skin, respiratory, digestive, or musculoskeletal problems in dogs – even a little reproductive problems.

Chiropractic Care
Chiropractors hold which misaligned vertebral column lessen a upsurge of impulses from a spinal connective hankie to a body’s muscles, viscera as good as tissues, as good as have been a means of a little illnesses as good as disorders. Veterinary chiropractors try to revive a upsurge of impulses by utilizing as good as adjusting specific physique joints as good as a joints in between a skeleton of a skull, additionally good known as cranial sutures.

Chiropractic treatments customarily assistance spinal problems, identical to a slipped front or pinched nerve. Some hold it can assistance in a little cases of epilepsy, skin disorders, as good as behavioral problems.

Physical as good as Massage Therapies

Physical care is mostly used to assistance rehabilitate an harmed dog or a single recuperating from surgery. There have been elementary techniques such as stretching, requesting feverishness or cold to a influenced area, as good as tailored array of amiable exercises. More endless treatments embody hydrotherapy or kick with low-level lasers, electricity, magnets, or ultrasound. Your veterinarian might suggest a single or a multiple of these treatments.

Massage therapy, where a therapist uses his or her hands as good as physique to rub a physique your dog’s soothing tissues, is mostly used after an injury. Muscle degeneration, cramps, dissemination problems, or soothing hankie injuries have been all problems which rub a physique care might help.

Homeopathy
Homeopathic diagnosis is a key of substances which furnish clinical signs identical to those of a mildew being treated with colour with colour in to a body. The thought is to yield a substances in amounts tiny sufficient to be harmless, nonetheless vast sufficient to inspire a physique to rise a antidote reply to a disease. Most substances come from plants, though a little have been extracted from animals as good as minerals. The piece is widely separated as good as done some-more manly as good as afterwards done in to a particle or glass form. Care contingency be taken not to make use of as well most of a substance, which in vast sufficient amounts might be toxic. That’s because it’s critical to select a veterinarian who has been prepared in homeopathic veterinary medicine.

Properly administered, homeopathic diagnosis can assistance a far-reaching accumulation of ailments, together with allergies, poisonings, wounds, viral infections, as good as a little diseases.

Botanical (Herbal) Medicine as good as Nutraceuticals
Plants have been a source of full of health remedies for a far-reaching operation of ailments. Many complicated drug have been subsequent from plants, though a drug go by containing alkali processing, which a little consider diminishes a plant’s strange recovering power. Sometimes a accumulation of spices which work together have been prescribed to yield your dog’s problem(s). In a little cases, a single herb is used to equivalent probable side goods of another. Make sure your veterinarian is prepared in herbal veterinary medicine, given a little plants have been toxic. Still others might be poisonous usually to sure class of animals.

Herbal remedies might be in effect for digestive problems, kidney or bladder disease, parasites, skin problems, or bone as good as hankie injuries.

Nutraceuticals have been nutritive supplements subsequent from animals or plants. They can be used to assistance dogs with a far-reaching accumulation of illnesses as good as diseases, including, though not singular to, corner problems, respiratory or digestive problems, or to foster a serve contentment of full of health dogs.

The future
There is a fast flourishing seductiveness in holistic as good as interrelated approaches to veterinary medicine. As investigate progresses, scientists have been guidance not usually what works, though how it works, as good as stability to urge a lives of a doggie companions.

Posted in Humor | 1 Comment

Good Old Days Before Scientific Medicine

CAM proponents are very fond of citing the antiquity and lineage, fictional or not, for their methods. Acupuncture, Traditional Chinese Medicine, and many herbal nostrums are promoted as “time-honored,” with the implication or explicit statement that anything people have been doing for so long must be a good thing. Foolishly expecting reason and logic to have some impact on this, we skeptics often try to point out that the number of people who believe something and the duration of time they believe it is not, unfortunately, a reliable indicator of whether or not it is BS. Or, as Tim Minchin more eloquently puts it in one of his songs, “I don’t believe that just because ideas are tenacious it means that they’re worthy.”

Soldiering on despite the blank stares or scoffing such a response often engenders, we continue to offer facts as rebuttal. The dramatic increase in life expectancy and health as scientific medicine came to replace traditional folk medicine seems a particularly salient fact in this context, but I recently ran across another smaller but more specific example of medical progress through time.

Dr. Atul Gawande, of Complications fame wrote an article for the New England Journal of Medicine in 2004 entitled Casualties of War–Military care for the wounded from Iraq and Afghanistan. As part of his discussion of care for wounded soldiers, he presented some historical statistics on the lethality of wounds suffered in combat by U.S. soldiers since the Revolutionary War. The table below illustrates the findings:

While we don’t have numbers from earlier eras or other countries, and while some caution is indicated in looking at numbers as old as those in the 18th and 19th centuries, the pattern is quite interesting. Survival varied, likely due in part to the reliability of the statistics, especially for small conflicts such as the Spanish-American War, but was consistently at or below 30% for most of the period until the 1950s. It improved to a consistent 25% for conflicts from then until the Iraq and Afghanistan conflicts and then improved dramatically. 90% of wounded soldiers can be expected to survive and come home, and while this raises legitimate questions about  how we ensure they have an acceptable quality of life and adequate help dealing with the lasting effects of their injuries, very few of them over the long term will likely prefer to have died. In this limited sense, such a change represents true progress in medical care for these servicepeople.

Dr. Gawande doesn’t address the changes prior to the current wars, but it seems likely that the development of antibiotics, blood replacement products, and other crucial developments in trauma care are responsible for the improvement after WW II. Gawande does delve into the details of the changes in medical practices that have dramatically improved survival in the current conflicts.

The point from the perspective of the difference between traditional and science-based medicine is that 1) the improvement coincides with major developments in scientific medical care which are often dismissed as irrelevant or even sources of harm and 2) medical practices are constantly being re-evaluated and improved based on measurable results. This is in stark contrast to the claims of those who argue for faith in tradition and received ancient wisdom.

Traditional folk medical practices have indeed often been around for centuries or even millennia, though these claims are sometimes exaggerated or fabricated by CAM advocates. However, in all those centuries or millennia, these methods have never succeeded in making the improvements in survival and health that have come in the last two hundred years, as Enlightenment rationality and scientific medicine have been born and matured. And these traditional practices are founded on the perceived virtue of not changing, whereas the ability to change and adapt that science gives mainstream medicine is one of its greatest strengths. This paper provides a small but clear illustration of the general case that the virtues of the scientific method demonstrably provide better results than the claimed virtues of tradition and longevity often attached to alternative medical practices.

Posted in General | Leave a comment

129th Skeptics’ Circle!

Good eveni…Is this on? Can you hear me in the back? Good, ok. Good evening ladies and gentlemen, and welcome to the 129th meeting of the Skeptics’ Circle. I’m SkeptVet, and I’ll be your MC this evening. Sorry, it’s my first time as MC, so I’m a bit nervous. Anyway, my Toastmaster’s class said I should open with a joke, so here goes..

I ran into Shirley McClain the other day, and I asked her, “Why did the chicken cross the road?”

She told me, “A chicken doesn’t cross the road when it crosses the road, and we know this because Stephen Hawking says we understand energy.”

Thank you, thank you, yes I’m here all week. For more skeptical chicken and road mockery, check out the ultimate collection at Skeptico.

Ok, we have a great lineup tonight, so let’s get right to it.

The august Dr. Aust considers the needs of those suffering from the recent earthquake in Haiti and suggests that while maybe sending money to aid organizations is a quiet, anonymous, not terribly dramatic way to help, it is better than arrogantly and flamboyantly rushing there to show off your woo, as some homeopaths have done. And now for something completely different (how many of you are old enough to remember that show?!) he takes an informative and surprisingly lighthearted look at Hitler and homeopathy.

Speaking of Haiti, I think we all know Pat Robertson had a few words to say on the subject. Well, The Skeptical Teacher has a few words to say back. Amen, brother! And on the subject of homeopathy, ST brings us a not-so-tragic story of one of our own, skeptic and atheist blogger Ziztur, who overcome by the meaninglessness of life (or by realization of the eternal gullibility of human beings) attempts to commit suicide with a homeopathic sleep aid. An entertaining and instructive, if futile gesture! Finally, The Teach also brings us a clip of Captain James T. Kirk interviewing someone even farther out in space than himself, psychotic–er, I mean–psychic John Edward. Set phasers for debunk!

And because woo is a global phenomenon, we have Stuff and Nonsense across The Pond pointing out the potential for confusion when discussing homeopathy and herbal remedies. Most homeopathic remedies are so dilute that they contain nothing but water and the hopes of their befuddled proponents. However, herbal remedies actually contain active compounds, for good or ill. Unfortunately, the two types of nostrums share many marketing points, including buzzwords like “natural,” which make it easy for consumers to confuse the two, with potential dangerous results.

Next, Akusai  at Action Skeptics takes on a subject I’ve also been known to rant about from time to time; the depressing decline in the quality of the Discovery Channel, from decent nature documentaries to “reality-TV” dreck and woo promotion. There are a few decent shows left, and Akusai reviews these and the rest in Discovery Channel- The Good, the Bad and the Ugly. Oddly enough, The Onion had a related story today entitled Science Channel Refuses to Dumb Down Science Any Further.

It’s been a tough winter already, but when not shoveling snow, Don Reifler of The Lafayette Skeptics has put together a comprehensive video presentation on the history of anti-vaccine activists called The March of the Mercury Militia which should be required background for anyone dealing with this particular anti-science bunch.

In the much warmer clime of South Africa, a nice local test of electromagnetic hypersensitivity syndrome I described by Paul Hutchinson, along with the disappointing lack of interest shown by sufferers in the results.

PodBlack Cat has for us an entertaining look at Superstition and the Olympics.

And continuing our look at medical nonsense, Bing over at Happy Jihad’s House of Pancakes has some thoughts to share with Grand Woomeister Mike Adams regarding his recent incoherent rant against skepticism, a temper tantrum precipitated by his losing to Dr. Rachel Dunlop (aka Dr. Rachie) for the Shorty Award in Health. These thoughts are incisive and cogent, and at least PG-13. Bing also has a proposal for an International Dr. Rachie Appreciation Day that merits serious consideration. I’ve taken the liberty of including a post from Dr. Rachie herself, showing a rare example of regulatory oversight actually calling BS on claims. And finally, Bing shares a few snapshots from his tour of the Creation Museum.

Also fighting the good fight against the imposition of the dangerous irrationality of religious fundamentalism on the rest of us, Ron Britton at the Bay of Fundie continues his extensive analysis of the Darwin Was Wrong “Conference”, which he infiltrated in November. Part 9: Fossil Fraud deconstructs the laughable attempts of one of the conference speakers to demonstrate why the fossil record is just God’s little joke, so we must abandon the notion of evolution all together. Good luck with that!

We get to enjoy three posts from Andrew Bernardin at Evolving Mind this time! First, he dissects the fuzzy “science” behind a study of the effects of stress after the Katrina disaster on children. Next, he shows us the connection between the anthropic principle and drunken billiards. Finally, he uses a bit of consumer research to help explain why good solid science is harder to market than vague nonsense.

Cubik’s Rube tells a wrenching horror story about Facilitated Communication and then follows it with a detailed and intelligent analysis of this practice and its implications. An excellent resource to point the credulous towards, and an excellent example of how to connect with people’s emotions to make them care about an issue without sacrificing reason and fact.

Who can foresee what the fickle winds of Fate will bring? In an unexpected stroke of good fortune, Lord Runolfr has won a valuable prize! Or has he…?

But wait! Perhaps the future isn’t so opaque after all. Hear Ye, Hear Ye! Red Stick Skeptic has had a vision! He has cast aside self-doubt and bravely proclaimed his ability to see the future, and woe to those who ignore his prognostications! I know all you closed minded skeptics out there are going to be keeping score, but I’ll bet he at least beats Sylvia Brown!

Well, I’m afraid that’s all we have time for tonight. I’m so glad we’ve had this time together. Just to have a laugh and sing a…What? Oh, sorry I thought I was supposed to sing.

The next Skeptics’ Circle, will be held at The Lay Scientist February 11, 2020. Please send more good stuff their way, at layscience@googlemail.com.

OK, good night everybody! Thanks for coming! Don’t forget to tip your waiters!

Posted in General | 6 Comments

Two Studies of Fish Oil for Canine Arthritis

One of the most popular nutritional supplements these days is fish oil. It contains a high proportion of omega 3 fatty acids (EFA), notable eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). This supplement is purported to have a broad range of beneficial effects in many disease conditions due to its effect on chemicals in the body involved in the inflammatory response (for more details see this article on eicosanoids). Some of these effects, such as a reduction in the rate of heart attacks in people with established heart disease and heart attack risk factors, are well-supported by research data. Other claims are less clearly valid. Several literature summaries are available from the Agency for Healthcare Research and Quality, and Medline.

In the veterinary arena, EFA supplements are widely used for allergic skin disease, with modest supportive clinical trial evidence (see also 1, 2, 3, 4).  In humans, there is limited evidence to support an effect on some clinical variables in patients with rheumatoid arthritis, and some have suggested osteoarthritis treatment as a veterinary application for these supplements. There is reasonable biologic plausibility to support investigating this use of EFA supplements, and two articles in a recent issue of the Journal of the American Veterinary Medical Association (JAVMA) report studies evaluating the use of fish oil supplements for dogs with confirmed osteoarthritis. I shall briefly review each of them.

The first study [1] was a multicenter, randomized, double-blind, placebo-controlled prospective study lasting 24 weeks. 167 dogs were randomized into two groups, one receiving a diet supplemented with EPA and DHA, the other receiving a pretty closely-matched control diet. There were no significant differences in any relevant variables between the groups at baseline. 23% of the dogs failed to complete the study (9% in the treatment group and 14% in the control group), and there were no significant differences between the groups with respect to these dropouts.

Assessment measures were subjective, with an owner survey and a clinical assessment by participating veterinarians. Dogs were evaluated at 6, 12, and 24 weeks after beginning the diets. Bloodwork showed significant increases in the blood levels of EHA and DHA in the dogs fed the test diet, so these substances were clearly absorbed. The owner survey evaluated 13 measures of comfort and function over three time periods (0-6 weeks, 6-12 weeks, and 12-24 weeks on the diets). Of these, 2 measures were significantly different between the groups at the first evaluation, and 1 measure was different at the last evaluation. There were no significant differences between the groups in clinical evaluation by veterinarians.

The study was apparently well-designed and well-conducted. The measures of outcome were subjective, which is less than ideal. It seems fairly clear that the results do not support the use of EFA supplementation for osteoarthritis. After all, out of 39 possible points at which the groups were compared in terms of owner evaluation only 3 showed changes not attributable to chance, and none of the evaluations by veterinarians showed significant difference. Unfortunately, the discussion section of the article is less an objective survey of the trial or the overall preponderance of the evidence than it is an attempt to put the most positive possible spin on the results.

The authors suggest their subjective measurement instrument may not have been sufficiently sensitive to detect a change and try to attribute the failure of the veterinarians to detect a difference to the hospital environment and limitations on clinical evaluation. They then conclude, “Our results suggest an ameliorative effect of omega-3 fatty acid supplementation in arthritic dogs,” and “ingestion of the test food….appeared to improve the arthritic condition in pet dogs with osteoarthritis.” Such a conclusion so clearly  at odds with the data presented in the report seems to be more an example of confirmation bias and cognitive dissonance than a reliable presentation of the evidence.

The second study [2] was conducted by several of the same authors. It too was a well-designed randomized, double-blinded, placebo-controlled, prospective study of the effects of dietary EFA supplementation on dogs with osteoarthritis. 44 dogs were enrolled in the study, and 14% failed to complete it (9% in the treatment group and 5% in the control group). Again there were no significant differences detected at baseline and no differences with respect to dogs that failed to finish the study. Both subjective and objective measures were evaluated at baseline and after 45 and then 90 days of the diets. Owner and clinician subjective evaluations were compared as were the results of force plate gait analysis.

In contrast to the previous study, there were no significant differences in owner evaluations of the subjects’ comfort and function. The authors attributed this to the low number of subjects rather than the more parsimonious explanation that there was no differences of sufficient magnitude to be noted. The clinician evaluations at 90 days showed significant differences from baseline for the test group in 3 of 5 measures. However, there were no significant differences between the test and control group for any measure.

The authors stated, correctly in my opinion, that “subjective assessment of limb function lacks repeatability as an outcome measure and is inferior to objective data obtained from force platform gait analysis.” Such an analysis was performed on all subjects. The results showed no change from baseline to 90 days for any of six variables measured (peak vertical force, vertical impulse, braking and propulsive peak forces, and braking and propulsive impulses). The test group did show a statistically significant difference in the mean percentage change in one measure, peak vertical force.

Again, these results provide lackluster support for the contention that EFA supplementation may be beneficial for dogs with osteoarthritis. Some subjective clinical measures showed a difference, but this is not consistent with the results of the other, larger trial, and the authors themselves minimized the significance of these results in both papers. One objective measure did show a statistically significant, and likely clinically significant change. However, the combined results of the two trials offer tepid support for the hypothesis under examination, and an interpretation of no meaningful effect seems much better supported by the results.

Unfortunately, the authors again spin these results in the most positive way possible:

“Together with the findings of our other study, findings of the study reported here supported the hypothesis that ingestion of fish oil omega-3 fatty acids improves clinical signs in dogs with osteoarthritis….Dietary supplementation with fish oil omega-3 fatty acids resulted in an improvement in weight bearing in dogs with osteoarthritis.”

The authors do acknowledge some of the limitations of their study and suggest that further research is necessary for definitive recommendations. I would agree that these results might justify further study, though I see no reason to expect dramatic findings of benefit. However, the reality is that in the world of veterinary medicine, with limited resources and clinical trial evidence, the more likely outcome of these reports is going to be an increase in the prescription for EFA supplements intended to treat osteoarthritis. The positive statements in the abstracts and discussion sections are likely to be the “take-home” message many readers get from the reports, despite the reality that the data is considerably less positive. I always appreciate well-designed and conducted research, but these reports emphasize the difficulty in conducting such trials without having an investment in their outcome that affects the interpretation of the results. This is a large part of why careful and critical evaluation of the primary literature for oneself is such a key component to sound, evidence-based practice.

References

1. Roush JK, Dodd CE, Fritsch DA, Allen TA, Jewell DE, et al. Multicenter veterinary practice assessment of the effects of omega-3 fatty acids on osteoarthritis in dogs. J Am Vet Med Assoc. 2010 Jan 1;236(1):59-66.

2. Roush JK, Cross AR, Renberg WC, Dodd CE, Sixby KA,, et al. Evaluation of the effects of dietary supplementation with fish oil omega-3 fatty acids on weight bearing in dogs with osteoarthritis. J Am Vet Med Assoc. 2010 Jan 1;236(1):63-73.

Posted in Herbs and Supplements | 24 Comments