Happy 5th Blogiversary to Me!

5th blogiversary

Though I’m a little late, I’m a forgiving sort, so I won’t be mad at myself for forgetting my blogiversary. June 4 marked five years of the SkeptVet Blog! The project has grown in so many ways. In the early days, I was excited to get fifty hits in a day, and in the last year it has been routine to get 800-1000 per day. Still small potatoes by Internet standards, but gratifying nonetheless. My goal has always been to provide a useful informational resource to pet owners and veterinarians, and to provide an alternative perspective on many therapies for which the only information on the internet is biased and unjustified marketing hype. The more people who know the blog is here, the more useful it is likely to be.

I have also expanded to discuss a much wider range of topics, even leaving the domain of alternative medicine more and more often. And in writing articles every week for five years, hopefully I have become a more effective communicator. I cringe when I look at the style and tone of some of my early posts, but I choose to view that as a good sign since it must mean I have grown and changed.

Writing this blog has provided me with opportunities to talk about evidence-based medicine more widely, to veterinarians and students and the general public, through my own lectures and presentations, writing opportunities, and interviews in the media. Hopefully, these activities will add an under-represented perspective, that of science and skepticism, to conversations within these communities about the best way to protect and restore health in our animal companions. I’ve never claimed to have all the answers, but I think I have some important and useful questions.

And writing this blog has certainly stimulated discussion and feedback. I have reviewed the negative comments before because I believe they are instructive in understanding the beliefs, values, and emotions that support pseudoscience and impede the effective use of science to improve veterinary medicine and animal health. But as an anniversary present to myself and those who find this project useful, I thought I’d review some of the positive feedback I’ve received. As well as being fun, this will help maintain the energy needed to keep going, which I fully intend to do. (All comments have been anonymized).

As a side note, another way to maintain this energy is going on vacation, which I will be doing starting this weekend. So activity, including responses to comments and emails, will be pretty light here for a few weeks. Never fear, I will keep up as best I can while I’m travelling, and I will dive back in with responses to your questions and comments and new articles with renewed vigor when I get back.

Finally, I offer a heartfelt “Thank you!” to all who have taken the time to provide supportive comments, questions or suggestions for topics to discuss, and thoughtful, substantive criticism. Your feedback does a great deal to neutralize the vacuous and angry responses a blog such as this inevitably draws and to maintain my faith in the possibility of civil, rational, fact-based discourse.

Thank you very much for taking the time to respond to my email and for providing a thoughtful response. .. Thank you for all the information you provide on your website as well.

Thank you. I asked my vet about XX again after I read your post…. I want to thank you for your honest “second” opinion before I started her on both meds. Knowing the possibility of “unknown” side effects makes me want to rethink…

Thank you very much for the information. .. Again, your advice is much appreciated in a difficult time for us.

I was very pleased the day I found your blog. You have excellent epidemiologic insight, which is rare among vets…. So, I applaud you for your post on media coverage of healthcare research.

Thank you so much for your timely response and thoughtful answers. I greatly appreciate you effort.

Thank you so much for your reply and the referenced article…Thank you so much for taking the time to answer my original email. I never expected to receive a reply, let alone a quick reply. The ACVIM Consensus Statement was extremely helpful.

I am so touched that you have replied so promptly and it is really fantastic to have such a well considered and scientifically based answer. Thank you very much, I truly appreciate it.

Thank you so much for your quick and detailed reply! I will be reviewing the links today. I so appreciate the work that you do and your personal reply to inquiries. I know that you receive a lot of negative feedback but I know there are also many, including myself, that appreciate your time, research, analysis and pragmatic consideration.   As a pet owner who loves her dog, I of course am in search of anything that won’t harm but could be helpful beyond the standard of care that we will be doing. I try to do diligent research on any recommended unconventional treatments.  Not just for my own dogs but when I am assisting in the treatment of patients at our hospital…This is something I take very seriously.  Reviewing your information I hope will help me make the best, most informed decision…

I just wanted to thank you for your blog. I have training in research design and statistical methods, but not as a biologist or veterinarian. I always want to read peer-reviewed research when something is wrong with my dog, but don’t understand the medical terms. Your blog is really a godsend. Keep up the good work!

I had originally intended to reply…in a private e-mail with encouragement and praise for speaking up for the rest of us in the “silent majority.”  Its a tough role to play and I continue to be impressed with your eloquence…Keep it up.

I’m so glad to see some common sense in the world. Your blog exposes a lot of the craziness which I really appreciate, especially coming from an MD background… It’s fascinating to me how quickly people gravitate towards alternative medicine, towards theories that sound magical and assume that they are just correct without any scientific evidence to back it up. Thanks for keeping it real!

I did try do my own review from primary literature, but I do not know the journals or the field at all, so your review was exactly what I was looking for, thank for that! My local vet now has a few extra facts to consider…As for the rest of your site, I enjoyed that too, and I’m very thankful that you take strong, and informed standpoints on CAM issues.

Good luck, and keep up the good work!

I wanted to drop a quick note to thank you for taking the time to post your thoughts and observations regarding various common and/or popular veterinary treatments…The net is long on anecdotes, short on science. Finding your blog has gone a long way towards filling the gap.

Just a quick thank you for your website and blog site. I’ve followed your sites for a while, and your citations to sources and reference materials are helpful in allowing me to share your information to family, friends, and our vets. The (sometimes) desperate urge to “do something” for our ailing pets clouds the minds of owners and vets alike, it seems. And some have a very hard time getting out the cloud.

First I wanted to thank you for posting your lecture, I shared it far and wide and hope that some of my colleges and friends were able to get what I was able to get out of it…Thank you for your response, your response far exceeded my expectations and I appreciate that.

You are doing a great service to pet companions of all stripes! we just struggled with putting down our beloved dogs in the past year, and the pressure to do all sorts of extraordinary but probably not effective treatments for them made it much more stressful.

Thank you so much for taking the time to reply!  Your message has helped very, very much.  We (pet people and their pets) are fortunate to have someone as thoughtful and generous as you are.

I’m new to your website as of today, came across it while searching for evidence-based information on dog food. What a great find! I completely appreciate your world view…Thank you for providing such a great source of well-researched and thought out information.

Just a quick note to tell you of my appreciation for you site. For years I have tried to educate my clients about the problematic proof supporting many of the alternative therapies other clinicians have been promoting… keep up the good work…

I appreciate your articles and perspectives. It’s so difficult to know how to best care for one’s pets in the face of so much contradictory information out there. .. Thanks so much!

Want to thank you for all of your efforts. Greatly appreciated and just hope that the folks who should be reading your site, somehow find it.

Thank you so much for your response. It is quite disheartening that there are so few veterinarians who are willing to speak out against organisations such as the American Council of Animal Naturopathy.

Skeptvet has superpowers It takes not only a extensive knowledge of vet medicine but the ability and time to put in writing that knowledge so others can understand the issues. I have seen other vets with extensive general small animal and human medicine knowledge. I have seen other vets that were great writers. But never a vet that had both knowledge with his ability to write. I find it difficult to believe only one person is at work here in this blog. It’s amazing what one person in the field of vet medicine is capable of accomplishing if they have the knowledge, training and dedication to do it.

Thanks for keeping it real, skeptvet, it’s frustrating to read some of the rants that occur here by those with an obvious ax to grind.

Skepvet, I’ve enjoyed the dialogue between yourself and dfg. I also appreciate your blog as source of information.

Thanks for the science-based common sense!

Thank you, Thank you !!! For writing such a clear, well documented and intelligent and thorough response and work.

Thanks for taking the time to compose this article…Your review was applicable and timely.

Hiya, just wanted to say and thanks. I’m getting a kitten and was considering a barf diet, but after doing my research, and coming across your site, I’m relieved to say I won’t be feeding my pedigree any raw food.

I just found this blog, and I’m so glad I did. There is way too much woo and pseudo-science out there for people who genuinely care about companion animals to wade through when trying to make informed choices on anything from medication and nutrition to training techniques.

Caveat emptor. Skeptvet, thank you for taking the time to elaborate. I found it helpful and I hope that others will as well.

Thank you for providing this valuable perspective.

I am still looking for the product I need. But, in the meanwhile I read your blog, loved it. Made perfect sense to me. And such a perfect way to confuse the writers, with fact.

Thanks for what you do generally, and specifically for providing a clear and reasonable overview of the literature on this issue. Like you and many others, I find the lack of quality controlled research here unfortunate

I am SO happy to have found your website! Will be following faithfully form now on. Thanks!!

Excellent blog post, as always, Skeptvet. Thank you for all you do.

Thank you again for producing this blog. I’m sharing this entry as part of my ethical duty to spread knowledge about the inefficacy of homeopathy.

Thanks for yet another well presented summary of the fallacies of magical thinking,

Thank you so much for this excellent summary based on SCIENCE.

Someone needs to stand up to faith masquerading as science, and people who would try to twist evidence to support their own agenda. Someone needs to hold the high ground when such people start flinging ad hominem abuse and sarcastic crap in defence of their idealism. But it’s so hard, and most of the time it’s a thankless task. I feel for you.

Thank you so much for offering a balanced view point of this.

Thanks for the facts. I trust a well argued appeal to reason and peer-reviewed evidence over the numerous emotional online sources decrying the substance.

Thank you thank you thank you ! The Dr. Dean Edell of veterinary medicine

Posted in General | 6 Comments

One More Time: Dogs are not Wolves!

Most everyone knows that dogs are descended from wolves. Anyone who has ever seen a dog and a wolf also knows that more than 10,000 years of active and passive selection by humans has had a dramatic transformative impact on the anatomy and physiology of the dog. Ancestry is not destiny, and the fact that dogs have wolf ancestors does not mean we should think of our pets as wolves or treat them as such.

I have made the point here many times that dogs are not wolves and that the notion of feeding them as if they were wild carnivores is lacking both sound logic and real evidence. A new study adds a small piece of additional evidence to the discussion.

Comparison of the fecal microbiota of wild wolves, dogs fed commercial dry diets and dogs fed raw meat diets. A. Sturgeon, C.M. Jardine, J.S. Weese. University of Guelph, Guelph, ON, Canada.

In this study, the authors looked at the microbial flora of 15 dogs (10 fed commercial kibble and 5 fed a raw meat-based diet) and 10 wild wolves and classified the types and proportions of bacteria present. The flora of the GI tract is a reflection of both the diet and the inherent biology of a species. The findings, not surprisingly, were that the flora of wolves and dogs were quite different. Wolves had a more variable flora than dogs, likely due to a more inconsistent diet. It is worth noting also that feeding dogs a raw meat-based diet did not alter the microbial flora to make it more like that of wolves.

As I have said many times, I don’t believe we have sufficient evidence to make strong claims about what is the optimal diet for dogs overall, much less for individual dogs with their own unique circumstances and needs. Conventional commercial diets are clearly sufficient to avoid obvious nutritional deficiencies, and millions of dogs live health, happy lives eating them. However, it would not surprise me at all to find that changes in these diets, or even a switch to a markedly different way of feeding our canine companions, would improve health and longevity in our pets. Science is a process which is never finished and in which all knowledge is provisional and subject to re-assessment.

However, we do our pets no favor by making dramatic changes in established feeding practices based on unsubstantiated theories or hunches without adequate evidence. As far as raw diets are concerned the theory behind them is weak, and there is currently little evidence concerning their health effects. More work will need to be done before it makes sense to claim these diets have benefits which outweigh their risks. The argument that we should be feeding these diets to our dogs because they are fundamentally wolves inside is not supported by the existing evidence, and it is not a sound reason to experiment with our pets’ health.

Posted in Nutrition | 49 Comments

Hilarious Takedown of Dr. Oz & Big Supplement’s Lobbying Against Public Health Regulation

John Oliver of Last Week Tonight (formerly of The Daily Show) provides a thoughtful, informative, and very funny report on the recent grilling of Dr. Mehmet Oz by Senator Claire McCaskill ansd the shameful success of the supplement industry lobbying Congress (especially Senators Orrin Hatch and Tom Harkin) to prevent sensible publich health regulations for dietary supplements. Bravo John!

 

Posted in Humor | 2 Comments

BSAVA Statement on Complementary & Alternative Medicine

Organizations representing veterinarians are fundamentally political in nature, and their leaders respond to the will of their constituencies. I have often written about the American Veterinary Medical Association (AVMA) in the context of alternative therapies and evidence-based medicine. While the organization has adopted some policies I believe are scientifically sound and in the best interests of veterinary patients and clients as well as veterinarians, there is no question that the group answers to veterinarians first and foremost, even when these conflict with the scientific facts or the interests of clients and patients. And within the veterinary profession, there are different and often competing constituencies that leaders of groups like the AVMA must respond to.

In regards to complementary and alternative veterinary medicine, CAVM, I have often been disappointed in the AVMA’s positions, though I understand the political realities that shape them. There is a constituency of pro-CAVM veterinarians which is small but vocal and well-funded. The constituency devoted to science and evidence-based medicine is smaller, less vocal, and not nearly as well-funded. And the large majority of veterinarians appear to have little interest or opinion concerning CAVM. This leads the AVMA as a whole to rather tepid positions on CAVM that reflect the political landscape far more than the scientific evidence.

The handling of the resolution introduced into the AVMA House of Delegates in 2012 discouraging the use of ineffective therapies, and specifically identifying homeopathy as such a therapy, illustrates the politics of CAVM within the AVMA. The science conclusively shows homeopathy to be nothing more than a placebo, despite attempts by homeopaths to claim otherwise, and the AVMA’s Council on Research supported this conclusion. However, the House of Delegates voted overwhelmingly against the resolution anyway because of vociferous opposition from pro-CAVM veterinarians, a general lack of interest in the scientific issues on the part of most members, and a deep cultural reluctance among veterinarians to criticize the practices of colleagues.

The AVMA also has a general statement on CAVM which used to be a fairly thoughtful, though still politically circumspect, document. It at least identified some core issues raised by the use of CAVM:

The theoretical bases and techniques of CAVM may diverge from veterinary medicine routinely taught in North American veterinary medical schools or may differ from current scientific knowledge, or both.

The AVMA believes that all veterinary medicine, including CAVM, should be held to the same standards. Claims for safety and effectiveness ultimately should be proven by the scientific method….Practices and philosophies that are ineffective or unsafe should be discarded.

The AVMA does not officially recognize diplomate-status or certificates other than those awarded by veterinary specialty organizations that are members of the AVMA American Board of Veterinary Specialties (ABVS), nor has it evaluated the training or education programs of other entities that provide such certificates. Recognition of a veterinary specialty organization by the AVMA requires demonstration of a substantial body of scientific knowledge. The AVMA encourages CAVM organizations to demonstrate such a body of knowledge.

The quality of studies and reports pertaining to CAVM varies; therefore, it is incumbent on a veterinarian to critically evaluate the literature and other sources of information. Veterinarians and organizations providing or promoting CAVM are encouraged to join with the AVMA in advocating sound research necessary to establish proof of safety and efficacy.

In this document, the AVMA refrained from passing judgment on the scientific merits of CAVM, but it at least acknowledged that science was the standard by which veterinary therapies should be judged and that, as of yet, few CAVM practices have met such a standard.

The new AVMA position on CAVM has been stripped of essentially all content and says merely that all therapies should be held to the same standard (without indicating what that standard should be) and that nobody should break the law. This revised statement moves further away from the notion that veterinary medicine is, or should be, a science-based profession. It reflects the growing political reluctance to make critical, evidence-based judgments about claims or practices so long as a licensed veterinarian is employing them.

Other veterinary organizations have been more faithful to the role of science as the foundation of veterinary medicine, with many specifically acknowledging the unacceptability of homeopathy in a science-based profession, and many identifying science and evidence-based medicine as essential to veterinary medicine.

A recent statement on CAVM from the British Small Animal Veterinary Association (BSAVA) takes a fairly moderate, political position on the issue of CAVM, though still one more robust than that offered by the AVMA. Like the previous AVMA statement, the BSAVA document acknowledges science and scientific research as the essential foundation for veterinary medicine, and explicitly endorses and evidence-based approach:

The BSAVA recommends that owners consider the evidence for a particular treatment and the qualifications and experience of the practitioner before embarking on any complementary or alternative therapy for their pet.

The BSAVA strongly recommends that whenever possible treatment decisions are based on sound scientific evidence to support the safety and efficacy of the therapy.

Assessing the evidence

Some people, including owners, therapists and veterinary surgeons, may perceive that the therapies work as a result of belief in the therapy (placebo effect); anecdotal evidence (extrapolation from hearsay or personal experience of a single or small number of cases) or errors in inference (cognitive bias).

There are three factors strongly associated with whether or not any one medical treatment is likely to be efficacious:

1. A rational scientific basis

Modern medicine works, and it works because it is founded on a scientific base. Although not all treatments used in conventional medicine have a strong evidence base in the sense of rigorous clinical trials showing their efficacy they do have a rational scientific / pathophysiological basis for their use.

2. Degree of certainty

The effects of some treatments are so clear cut that further testing is not required. It has famously been pointed out that rigorous clinical trials are not needed to prove that parachutes reduce morbidity and mortality among people falling from aeroplanes. Similarly, one does not need rigorous trials to show that intravenous anaesthetics cause a rapid, profound loss of consciousness suitable for carrying out surgery. However, the effects of many treatments are much less certain; e.g., they are less closely associated in time with their effect, or the effect caused is much less dramatic, smaller and/or more variable in magnitude and/or time of onset. In such circumstances, given the variable time courses of many diseases, it can be remarkably difficult to determine whether a given treatment is actually efficacious or not.

3. Evidence

When there is anything less than absolute certainty about the efficacy of a treatment, then evidence is important in deciding whether a treatment is safe and efficacious. However, history has also shown that evidence – both in the form of clinical experience and individual clinical research results – can be misleading. The process of evidence-based (veterinary) medicine exists to improve our confidence by formally and systematically searching for all of the relevant evidence and formally and systematically grading the quality and reliability of that evidence.

The organization also acknowledges that the evidence for most CAVM is poor and that safety or efficacy is largely unknown for many CAVM practices:

Health claims for many complementary and alternative therapies are far in excess of the available scientific data, and sometimes in frank contradiction to scientific evidence.

In making decisions about the use of complementary and alternative therapies it is important to consider their safety and efficacy. Many people assume that all complementary and alternative therapies are natural and therefore safe, but this is not always the case. All therapies may produce unwanted side effects or may interact with other therapies. In the case of alternative therapies it is also important to consider the welfare implications of withholding conventional treatments.

There is a great deal of variation in both the degree to which various complementary and alternative therapies have been scientifically tested, and to which such testing has provided evidence supporting their efficacy.

While I believe it would have been appropriate to go further and acknowledge that at least some CAVM practices are completely without merit and should be discouraged, such as homeopathy and so-called “energy” therapies, I think this is a solid statement supporting the important role of science in veterinary medicine. Relying on science to understand and predict nature has led to far greater health and well-being and far less physical suffering than human beings, and our animal companions, experienced in all the thousands of years before we developed the scientific method. Acknowledging the unparalleled power of science to guide us to the right answers in healthcare is essential in maintaining and extending the gains science has allowed medicine to achieve.

This statement seems to indicate that the constituency of the BSAVA, like that of other veterinary groups in Europe and Australia, is moving in the right direction with respect to deepening the reliance on science and evidence-based medicine in the veterinary field. Sadly, the recent actions of the AVMA would suggest that here in America, as seems evident in many other areas, we are moving in the wrong direction, away from rationalism and science and towards an epistemology that privileges personal experience and belief over objective, scientific evidence. This is not in the best interests of our patients, our clients, or our profession.

Posted in Law, Regulation, and Politics | 1 Comment

JustFoodForDogs Brings Us Some Classic Marketing Masquerading as Science

I have written about the issue of homemade pet diets here several times (1, 2, 3, 4). They are appealing to some owners because they appear more “natural” than commercial dry or canned diets, which is supposed to imply they are better for pets. And, of course, many proponents of alternative medicine make hysterical and unsupported accusations about the dangers of conventional pet diets.

People also equate conventional commercial pet food with what is typically called “processed food,” though they are entirely different things. Human snack foods and other processed foods are laden with excessive sugar, salt and fat and generally nutritionally poor. Commercial pet foods, if properly formulated and manufactured, are nutritionally balanced to a greater degree than our haphazard diet of whatever looks appealing in the moment, even when we the packaged junk foods are avoided.

Homemade diets can be perfectly healthy, and there are circumstances in which a diet formulated for the specific needs of a particular pet is better than any commercially available diet. And fresh food is certainly attractive to many pets. But the dramatic claims of health benefits made for them are entirely unproven, and the existing research suggests most recipes for homemade diets, even those promoted by veterinarians, are not appropriately balanced nutritionally and not ideal for long-term health. I encourage anyone interested in preparing food at home for their pets to consult with a board-certified veterinary nutritionist for guidance.

I recently ran across a press release from a company which appears to be trying to cash in on fears of commercial pet food and the appeal of homemade diets in order to sell—you guessed it, their commercial pet food. Reminiscent of the “just like homemade” marketing approach often used to sell packaged foods for people,  JustFoodForDogs makes heavy use of terms like “scientific” and “evidence” in their marketing to suggest that dry commercial diets and the ingredients they contain are unsafe and that their packaged frozen cooked diets are better. While these diets appear to meet all the same standards for balanced nutrition of other commercial diets, including AAFCO feeding trial tests, the evidence offered for their superiority is so far scant.

One unpublished study funded by the company and run by one of their veterinarians is referred to in their press release as “groundbreaking” and “game changing.” Science by press release is always a bad sign (anybody remember “cold fusion?”), but the presentation of the study is clearly designed to maximize its marketing value without providing any of the information that would be needed to determine if the methods were really appropriate.

Twenty-one dogs of unspecified breeds were fed some of the company’s diets (the details are not reported) and basic bloodwork and exams were conducted at the beginning of feeding the diet and again at 6 months and twelve months. No control group, no blinding, no pre-specified outcomes or hypotheses, no reported accounting for repeated measures or multiple comparisons in the statistical analysis, no discussion of any other aspects of the dogs health or environment, and overall none of the hallmarks of an actual controlled clinical study. All of this would be fine of the purpose were merely to explore the effects of the diet and generate hypotheses. But the company clearly intends to present these results as earthshattering, paradigm-shifting research that (coincidentally?) favors their product.

And after setting up everything with no apparent effort to control for the obvious risk of bias, what were the reported results? One kind of blood protein, globulins, went up (by how much isn’t disclosed). Some kinds of white blood cell numbers increased (again, by how much isn’t disclosed, but the numbers were apparently still within the range of normal). And one measure of red blood cells increased, though another did not.

Given the comparisons of many different values with no explicit reason and no reported use of statistical methods to control for making them, it is almost guaranteed some values would change to a degree judged “statistically significant.” This is not the same thing as medically significant, and there is no evidence these changes had any clinical relevance, especially with no control group for comparison. But the company promotes the results as showing their foods “could benefit immune health” and that if the purported trends in the blood values continue for the animals’ lifetimes “we may see a decrease in chronic diseases such as cancer, renal failure, kidney disease, inflammatory bowel disease, dental disease, etc.”These results certainly don’t support anything even approaching such claims.

The hypothesis that fresh foods could have health advantages over extruded kibble or commercial diets is not an unreasonable one, and I am open to the possibility this might be true. But this is not something we can simply assume without evidence, and that evidence does not yet exist. Furthermore, the claims made about the dangers of conventional commercial diets are rarely supported by evidence either, whereas there is abundant scientific research and real-world experience showing that pets can live long, health lives on these foods.

If the folks behind this company genuinely believe their claims about health and nutrition, and I have no reason to think they don’t, then they should make an effort to design and conduct properly controlled scientific research to evaluate their hypotheses. But they do a disservice to pets and pet owners when they perform “studies” clearly designed with marketing rather than science in mind, hype the results to an extreme degree, and then use this as a marketing strategy to promote their own products.

Posted in Nutrition | 82 Comments

Liberals not Immune to Science Denialism

This should be mandatory viewing in every Starbucks, Pilates class, and Whole Foods in America!

 

 

Posted in Humor | 1 Comment

American Holistic Veterinary Medical Association (AHVMA) & its Foundation (AHVMF)

I recently received a registration packet for the 2014 Annual Conference of the American Holistic Veterinary Medical Association. This seemed a good reminder to pull together some of the information and observations concerning organized alternative veterinary medicine I have posted in the past.

I have written frequently about the American Holistic Veterinary Medical Association (AHVMA) and the spinoff group the American Holistic Veterinary Medical Foundation (AHVMF). These organizations are the tip of the spear, so to speak, of the effort to promote alternative therapies in veterinary medicine. They mimic the organizational structure and functions of the American Veterinary Medical Association (AVMA) and many other veterinary professional organizations, and they appear on the surface no different. In fact, the AHVMA recently became large enough to qualify for a seat in the governing House of Delegates of the AVMA as an affiliate organization.

These groups are very successful financially (AHVMA and AHVMF financial statements), with combined revenue in 2012 of over a million dollars. These resources give them influence, as illustrated by their donations to veterinary medical colleges intended to create or support the integration of alternative therapies into the curriculum. In 2012, the AHMVF announced a grant of $10,000 to the University of Tennessee to support an integrative medicine program, and another $40,000 grant to support an integrative medicine fellowship (though the tax filing only lists the $40,000 amount). The same year, the AHVMF announced a $200,000 grant to the University of Louisiana, for the formation of an integrative medicine program and the hiring of a faculty member trained in Chinese Veterinary Medicine (though again, the tax filing reported different numbers, with only $110,000 given to the university). They also reported over $13,000 in scholarships for students to support studying alternative veterinary medicine.

All of this is a good thing, if you believe that alternative/holistic/integrative medicine is a collection of safe and effective approaches to healing pets. If, however, you are committed to science as the best way to understand nature and to develop safe and effective medicine, well the success of these organizations should be troubling. The activities of these groups and the statements of their leaders have consistently demonstrated a superficial respect for scientific methods masking a deep philosophical rejection of the basic principles of science and evidence-based medicine. Yet their activities, and the influence of their financial resources, create the appearance of legitimacy for many therapies that are at least dubious and unproven, and often complete quackery.

Both organizations share a clear mission of advocacy and promotion of alternative therapies. While the AHVMF often claims to be interested in research into alternative approaches, it is clear that approach here is to use science the way a drunk uses a lamppost–for support, not illumination. The goal is to generate the appearance of positive scientific research findings and validation, but there is no serious willingness to follow where the evidence leads or reject practices when the scientific evidence against them is overwhelming. This is made starkly clear by the aggressive lobbying of the AHVMA against the resolution considered last year by the AVMA to declare homeopathy an ineffective therapy. Despite the clear scientific consensus that after 150 years of study homeopathy has been proven to be nothing more than a placebo, the AHVMA stood behind a clearly misleading collection of pseudoscience put forward by the Academy of Veterinary Homeopathy (AVH), and proudly trumpeted the defeat of the resolution as a victory.

I have reviewed the proceedings available for a couple of AHVMA meetings in the past, 2009 and 2012. While there were sessions on some promising but as yet unproven methods (for example herbal remedies and dietary supplements and cold laser therapy), there were many on the Big Three of alternative medicine (acupuncture, chiropractic, and homeopathy), and plenty on other varieties of nonsense, from Traditional Chinese Veterinary Medicine to shamanism, to Earth Acupuncture, and so on. The tone of the majority of speakers clearly showed a deep philosophical rejection of science in favor of vitalism and the tyranny of the anecdote and personal experience. The offerings at the 2014 conference appear to be much the same, with a few new ”hot topics” (leech therapy, bee venom therapy, and medical uses of marijuana, for example).

I have also previously written about the funding for these meetings, which provides a major source of income for the AHVMA. They draw sponsorship from a wide range of commercial organizations, mostly those providing products and services used by alternative veterinary practitioners. These include manufacturers and distributers of herbal products, dietary supplements, laser equipment, unconventional foods such as raw diets, and companies which teach alternative therapies, such as the Chi Institute (the full list for 2104 is available here).

The point in mentioning this is not to suggest that these groups should do without such funding sources. The reality is that no veterinary education or outreach activity can occur without some source of funding, and that inevitably means working with related industries. However, the potential influence of this money on the practices employed by veterinarians and on the generation and interpretation of scientific evidence concerning these is a legitimate concern. Proponents of alternative medicine are quick to remind us of this when criticizing the use of pharmaceuticals and the potential influence of Big Pharma on conventional doctors, but they seem reluctant to acknowledge that their own activities are no freer from the influence of commercial funding.

Because the AHVMA and AHVMF are influential organizations and, in my opinion, are primarily promoting pseudoscience and anti-science in veterinary medicine, I try to keep track of their activities. So I have added this post to my list of topic-based summaries and will try to keep an up-to-date collection of relevant posts here.

Posts Related to the AHVMA and AHVMF

Dr. Nancy Scanlan Shows us How to Talk Sciency Without Really Accepting Science

Dr. Barbara Royal Reminds us that the AHVMF Opposes Science-Based Medicine

The 2012 AHVMA Annual Conference: An illustration of Conflicts between Science-Based Medicine and Holistic Veterinary Medicine

Leader of Holistic Veterinary Foundation Express some Troubling Ideas about Science

American Holistic Veterinary Medical Foundation gives $10,000 to University of Tennessee Veterinary School to Promote Alternative Medicine

Response to Comments from the American Holistic Veterinary medical Association on the AVMA Homeopathy Resolution

The American Holistic Veterinary Medical Foundation (AHVMF): Science of Salesmanship?

Politics Trumps Science: Continuing Education Credit for Pseudoscience Thanks to the AHVMA

The AHVMA: Bought and Paid for by Big Supplement?

“Holistic Medicine:” It Means Whatever We Say It Means

Woo U. — CAVM as Continuing Education for Veterinarians

 

Posted in Topic-Based Summaries | 13 Comments

Evidence Update-Chinese Studies of Acupuncture Are Always Positive: Perfect Medicine or Hidden Bias?

What many people don’t realize about scientific studies is that since they are designed, conducted, analyzed, and reported by fallible human beings, they are prone to all sorts of bias and error. They often contain mechanisms to minimize these sources of error, which is why they are still more reliable than personal experience, history, and other uncontrolled sources of information. And, of course, the best compensation for the failings of individual scientists is the work of other scientists, critiquing the work, trying to replicate it, and generally bashing it about until the truth falls out. Science is a community endeavor, and the community keeps the individual honest. At least, that’s the theory.

However, some communities prize this sort of critical, competitive error correction process more than others. I have written often about the general tendency of people in the alternative medicine community to prefer unity and validation of each other’s theories to rigorous, skeptical scrutiny aimed at paring away bias and error. As a category, Alternative Medicine only exists to protect some practices from the standards of evidence scientific medicine are expected to conform to. If these therapies can prove themselves by accepted scientific means, they are not “alternative” or “complementary” and wouldn’t need to be “integrated” with regular medicine because they would simply be regular medicine.

One example of the misuse of science to confirm and support rather than challenge excepted beliefs is the literature concerning acupuncture. The vast majority of acupuncture studies are done in countries where it is a widely accepted practice (though not as widely as sometimes claimed), and where most practitioners and others already accept its effectiveness. China, in particular, contributes a tremendous percentage of the research on acupuncture. And as I’ve discussed before, there is strong evidence that Chinese acupuncture studies are biased in favor of acupuncture. This evidence includes studies which have shown negative results of acupuncture research are almost never published, studies are often inaccurately reported as randomized when they aren’t, and systematic reviews often selectively search and report the literature in ways that are favorable to acupuncture. Yet another study has now been published which confirms that Chinese researchers simply do not produce or report negative results for acupuncture.

Yuyi Wang, Liqiong Wang, Qianyun Chai, Jianping Liu. Positive results in randomized controlled trials on acupuncture published in chinese journals: a systematic literature review. J Altern Complement Med 2014 May;20(5):A129

This review found 847 reported randomized clinical trials of acupuncture in Chinese journals. 99.8% of these reported positive results. Of those that compared acupuncture to conventional therapies, 88.3% found acupuncture superior, and 11.7% found it as good as conventional treatments. Very few of the studies properly reported important markers of quality and control for bias such as blinding, allocation concealment, and losses to follow-up.

Of course, one could argue that the failure to publish negative results, and the overwhelming superiority of acupuncture compared with conventional treatments is evidence that acupuncture is incredibly effective and that Chinese researchers do a nearly perfect job of employing it. That seems a pretty implausible interpretation, however, It would suggest that acupuncture is unlike any other therapy ever tested scientifically, and that Chinese acupuncturists are nearly perfect clinicians. It would also beg the question of why acupuncture was practiced in one form or another for thousands of years without meaningfully improving the life-expectancy or mortality patterns of people in China while science-based medicine has dramatically extended life and reduced disease there as everywhere else.

A more likely interpretation of this and the other studies showing that the Chinese almost never report failures in acupuncture treatment is simply that the design, conduct, and reporting of these studies is biased towards supporting the already widespread belief that acupuncture works. Belief trumps and distorts science all the time, and this is likely yet another example of this. All kinds of cultural theories can be advanced to explain these findings, and the differences between the acupuncture literature in China and that in the English language literature, where negative studies are much more common. I am no sociologist, but I do know that science exists specifically as a method for combating the natural human tendency to seek confirmation rather than refutation of our existing beliefs, and that no system for checking human bias can be successful without an explicit commitment to following the methods and accepting the results even when they are not consistent with what we want to believe.

I have talked previously about the dangers of alternative medicine research functioning as marketing and propaganda rather than a careful and genuine effort to seek the truth. The analysis of the Chinese literature pertaining to acupuncture, and most of the literature related to homeopathy, illustrate this danger. It is imperative that scientific evaluation of alternative therapies be held to at least as high a standard as research on conventional treatments is in order to prevent people, and our pets, from being subjected to ineffective or unsafe therapies under the misguided belief that they have been proven to work.

Posted in Acupuncture | Leave a comment

Update-Do Dogs Defecate in Alignment with the Earth’s Magnetic Field?

Earlier this year, I reviewed a research study claiming that dogs orient themselves to fluctuations in the earth’s magnetic field when defecating. I was asked to re-post the review on Publons, a site which publishes reviews of journal articles. The authors have posted a response there which answers some concerns I expressed in my review, but which also illustrates some of the same misconceptions about statistics and hypothesis testing that I originally discussed. I have responded both here and on the Publons forum.

The summary of the reactions of the media on our paper is very fitting and we agree. The critic of our study is, however, biased and indicates that the author did not read the paper carefully, misinterpreted it in some cases, and, in any case is so “blinded” by statistics that he forgets biology. Statistics is just a helpful mean to prove or disprove observed phenomena. The problem is that statistics can “prove” phenomena and relations which actually do not exist, but it can also “disprove” phenomena which objectively exist. So, not only approaches which ignore proper statistics might be wrong but also uncritical sticking on statistical purity and ignoring real life.

To begin with, I believe the author and I agree that statistics are easily and commonly misused in science. Unfortunately, this response seems to perpetuate some of the misconceptions about the role of statistics in testing hypotheses I discussed in my original critique.

Statistics never prove or disprove anything. Schema such as Hill’s Criteria of Causation and other mechanisms for evaluating the evidence for relationships observed in research studies illustrate the fact that establishing the reality of hypothesized phenomena in nature is a complex business that must rest on a comprehensive evaluation of many different kinds of evidence. It is unfortunate that p-values have become the sine qua non of validating explanations of natural phenomena, at least in medicine (which is the domain I am most familiar with). The work of John Ionnidis and the growing interest in Bayesian statistical methods are examples of the move in medical research to address the problem of improper use and reliance on frequentist statistical methods.

That said, these methods do have an important role in data analysis, and they contribute significantly to our ability to control for chance and other sources of error in research. The proper role of statistical hypothesis testing is to help assess the likelihood that our findings might be due to chance or confounding variables, which humans are notoriously terrible at recognizing. If we employ these tools improperly, then they cease to fulfill this function and instead they generate a false impression of truth or reliability for results that may easily be artifacts of chance or bias.

The authors accuse me of being “so ‘blinded’ by statistics that he forgets biology.” This is ironic since their paper uses statistics to “prove” something which a broader consideration of biology, evolution, and other information would suggest is improbable. Even if the statistical methods were perfectly and properly applied, they would not be “proof” of anything any more than improper use of statistics would be definitive “disproof” or the authors’ hypothesis. While I discussed some concerns about how statistics were used in the paper, my objections were broader than that, which the authors do not appear to acknowledge.

The author of this critic blames us of “data mining”. Well, first we should realize that there is nothing wrong about data mining. This is an approach normally used in current biology and a source of many interesting and important findings. We would like to point out that we have not “played” with statistics in order to find out eventually some “positive” results. And we have definitively not sorted data out. We just tested several hypotheses and always when we rejected one, we returned all the cards (i.e. data) into the game and tested, independently, anew, another hypothesis.

Though I am not a statistician, I believe there is a consensus that while exploratory analysis of data is, of course, appropriate and necessary, the post-hoc application of statistical significance tests to data after patterns in the data have already been observed is incorrect and misleading. This is what the paper appeared to suggest was done, and this would fit the definition of inappropriate data-dredging.

Note also that we performed this search for the best explanation in a single data sample of one dog only, the borzoi Diadem, for which we had most data. When we had found a clue, we tested this final hypothesis in other dogs, now without Diadem.

This was not indicated in the description of the methods provided in the original paper. If the exploratory analysis was done with one data set while the authors remained blind to the data set actually analyzed in the paper, then that would be an appropriate method of data analysis. The subsequent statistically significant results would not, of course, necessarily prove the hypothesis to be true, but they would at least reliably indicate the likelihood that they were due solely to chance effects.

This does not, however, entirely answer the concern that the study began without a defined hypothesis and examined a broad range of behaviors and magnetic variables in order to identify a pattern or relationship. As exploratory, descriptive work this is, of course, completely appropriate. But the authors then use statistical hypothesis testing to support very strong claims to have “proven” a hypothesis not even identified until after the data collection was completed. This seems a questionable way to employ frequentist statistical methods.

Let us illustrate our above arguments about statistics and “real life” on two examples. Most medical diagnoses are done through exclusion or verification of different hypotheses in subsequent steps. Does it mean that when the physician eventually finds that a patient suffers under certain illness, the diagnosis must be considered improbable because the physician has already before tested (and rejected) several other hypotheses?

This analogy is inapplicable. The process of inductive reasoning a clinician engages in to seek a diagnosis in an individual patient is not truly analogous to the process of collecting data and then evaluating it statistically to assess the likelihood that patterns seen in the data are due to chance. Making multiple statistical comparisons, particularly after one has already sought for patterns in the data, invalidates the application of statistical hypothesis testing. The fact that in other contexts, and without the use of such statistical methods, people consider possible explanations and then accept or reject them based on their observations is irrelevant.

Or imagine that we want to test the hypothesis that the healthy human can run one kilometer with an average speed of 3 m/s. We find volunteers all over the country who should organize races and measure the speed. We shall get a huge sample of data, we have an impression that our hypothesis is correct but the large scatter makes the result insignificant. So we try to find out what could be the factors influencing speed. We test the age – and find out that indeed older people are slower than younger ones, so we divide the sample into age categories, but the scatter is still too high, so we test the effect of sex, we find a slight influence, but it still cannot explain the scatter, we test the position of the sun and time of the day, but find no effect, we test the effect of wind, but the wind was weak or it was windless during races, so we find no effect. We are desperate and we visit the places where the races took place – and we find the clue: some races were done downhill (and people ran much faster), some uphill (and people ran much slower), those who ran in flat land ran on average with the speed we expected. So we can now conclude that our hypothesis was correct and moreover we found an effect of the slope on running speed. We publish a paper describing these findings and then you publish a critic arguing that our approach was just data mining and was wrong and hence our observation is worthless and that the slope has no effect on running speed at all. Absurd!

Again, this example simply describes a process for considering and evaluating multiple variables in order to explain an observed outcome, which is not the objection raised to the original paper. If the only hypothesis in a study such as described here was that at least one human being could run this fast, then a single data point would be sufficient proof and statistics would be unnecessary. However, if one is trying to explain differences in the average speed of different groups of people based on the sorts of variables mentioned, the reliability of the conclusions and the appropriateness of the statistical methods used would depend on how the data was collected and analyzed. In any case, nothing about this has any direct relevance to whether or not the data collection and analysis in the original paper was appropriate or justified the authors’ conclusions.

As I said in the original critique, this study raises an interesting possibility; that dogs may adjust their behavior to features of the magnetic field of the earth. The study was clearly a broadly targeted exploration of behavior and various features of the magnetic environment: “we monitored spontaneous alignment in dogs during diverse activities (resting, feeding and excreting) and eventually focused on excreting (defecation and urination incl. marking) as this activity appeared to be most promising with regard to obtaining large sets of data independent of time and space, and at the same time it seems to be least prone to be affected by the surroundings.” It did not apparently start with a specific, clearly defined hypothesis and prediction, so in this sense it seems an interesting exploratory project.

However, with such a broad focus, with mostly post-hoc hypothesis generation, and with a lack of clear controls for a number of possible alternative explanations, the study cannot be viewed as definitive “proof” of the validity of the explanation the authors provide for their observations, though this is what is claimed in the paper: “…for the first time that (a) magnetic sensitivity was proved in dogs, (b) a measurable, predictable behavioral reaction upon natural MF fluctuations could be unambiguously proven in a mammal, and (c) high sensitivity to small changes in polarity, rather than in intensity, of MF was identified as biologically meaningful.”

I agree with the authors that their results are interesting and should be a stimulus for further research, but I do not agree that the results provide the unambiguous proof they claim. As always, replication and research focused on testing specific predictions based on the hypothesis put forward in this report, with efforts to account for alternative explanations of these observations, will be needed to determine whether the authors’ confidence in their findings is justified.

 

Posted in General | 1 Comment

Shocking News! Media Coverage of Healthcare Research Often Not Very Good.

As a veterinarian, explaining science to non-scientists and interpreting the meaning of scientific research is a key part of my job. Pet owners cannot make truly informed decisions about what to do for their animal companions without reliable information they can understand. This blog arose out of my efforts to provide better information to my clients, and it has led to further efforts to inform the public, and my colleagues in veterinary medicine, about how to evaluate medical interventions and understand the scientific research we need to support making decisions for pets.

My own knowledge about how we understand health and disease has come from many years of academic study. This includes a master’s degree I will be finishing this year in epidemiology, the branch of science specifically devoted to understanding health and disease and generating safe and effective healthcare interventions. And hopefully I have developed some ability to effectively communicate about science through my academic background, my years as a veterinarian, and my work speaking and writing for the veterinary community and, of course, in this blog.

In a sense, this blog has made me part of “The Media,” as has my involvement with the American Society of Veterinary Journalists. Unfortunately, taken as a whole “The Media” does not do a very good job of covering scientific topics, and journalists seem to contribute to misconceptions at least as often as they dispel them. A newly published study looking specifically at media coverage of healthcare research illustrates this starkly.

Schwitzer GA. A Guide to Reading Health Care News Stories. JAMA Intern Med. Published online May 05, 2014. doi:10.1001/jamainternmed.2014.1359

This paper reports on a 7-year evaluation of media stories from print and electronic media of various kinds. It details a number of specific errors in how journalists often present and interpret scientific research that lead to a false understanding of what the results mean. The conclusion of the study was

After reviewing 1889 stories (approximately 43%newspaper articles, 30% wire or news services stories, 15%online pieces [including those by broadcast and magazine companies], and 12%network television stories), the reviewers graded most stories unsatisfactory on 5 of 10 review criteria: costs, benefits, harms, quality of the evidence, and comparison of the new approach with alternatives. Drugs, medical devices, and other interventions were usually portrayed positively; potential harms were minimized, and costs were ignored.

The specific kinds of mistakes made in many stories about healthcare research struck me not only because I see them all the time in the media, but because they mirror very closely exactly the sorts of mistakes made by advocates of alternative therapies. Though this study did not, unfortunately, look specifically at coverage of alternative medicine, my subjective impression is that the media makes the same sorts of errors but is even less careful and critical in coverage of this area. Pieces on veterinary medicine, in particular, are often poor quality because they are part of the “lifestyle” or “human interest” beat rather and treated as entertainment rather than being written by qualified science journalists interested in the truth about healthcare practices.

In any case, here are the major problems the study identified in media coverage of healthcare science:

Risk Reduction Stated in Relative, Not Absolute, Terms
Stories often framed benefits in the most positive light by including statistics on the relative reduction in risk but not the absolute reduction in risk. Consequently, the potential benefits of interventions were exaggerated.

While journalists are often understandably loath to talk about anything that sounds like math, it is impossible to appropriately talk about the effects of medical therapies without identifying the difference between absolute and relative risk. If you have a 1 in a million chance of developing a terrible disease, and something raises your chances to 2 in a million, that is a relative risk increase of 100%. Sounds terrible! But the thing is, at a chance of 2 in a million, you are still almost certainly not going to get that disease. And doubling your risk does not make it meaningfully more likely that you will. Such a simple distinction is critical to deciding whether medical interventions are worthwhile

Failure to Explain the Limits of Observational Studies
Often, the stories fail to differentiate association from causation.

You may have heard the saying “correlation does not mean cause and effect.” Just because two things are associated doesn’t mean one caused the other. If, for example, a study found that carrying matches in your pocket was associated with an increase in your risk of lung cancer of ten times, would that mean matches cause lung cancer? Of course not! Carrying matches may mean you’re a smoker, and smoking certainly does cause lung cancer, but the simple association between matches and cancer doesn’t mean one causes the other.

Here’s a great site that illustrates all kinds of such bogus associations. While this may not be something everyone appreciates in daily life, journalists writing about healthcare research ought to understand it.

The Tyranny of the Anecdote
Stories may include positive patient anecdotes but omit trial dropouts, adherence problems, patient dissatisfaction, or treatment alternatives.

I’ve written about anecdotes and miracle stories many times. The number one “argument” presented in the comments on this blog in defense of treatments I evaluated critically is the presentation of anecdotes that look like they show the treatment working. Anecdotes can only suggest hypotheses to test, but they can never prove these hypotheses true.

There are many reasons treatments that don’t work may seem like they do, and professionals who interpret and explain science should know anecdotes are unreliable and often misleading. While personal stories make for more interesting and emotionally appealing narratives, they should always be used carefully only to illustrate something that has been demonstrated to be true or false by more reliable evidence.

Surrogate Markers May Not Tell the Whole Story
Journalists should distinguish changes in surrogate markers of disease from clinical endpoints, including serious disease or death. Many news stories, however, focus only on surrogate markers, as do many articles in medical journals.

The bottom line for any medical treatment is whether it reduces the meaningful symptoms of disease, including the most final of all, death. It makes no difference if a therapy raises or lowers the amount of some chemical we can measure in the blood if that isn’t a clear and well-established indicator that the therapy will also reduce suffering or prevent death. Surrogate markers are, as the article suggests, overused by healthcare researchers in many cases because they are often cheaper and easier to measure than real symptoms or mortality, but they have significant limitations, and this should be made clear when talking about research using them.

Stories About Screening Tests That Do Not Explain the Tradeoffs of Benefits and Harms
Stories about screening tests often emphasize or exaggerate potential benefits while minimizing or ignoring potential harms. We found many stories that lacked balance about screening for cardiovascular disease and screening for breast, lung, ovary, and prostate cancer.

I have frequently referred to the growing appreciation in human medicine, which has not yet come very far in the veterinary field, that screening tests have risks as well as benefits, and these need to be carefully weighed. The Choosing Wisely project is a key resource for people trying to make smart decisions about screening tests, as is the web site for the U.S. Preventative Services Task Force. Both provide real evidence to help balance the risks and benefits of potential screening tests. Journalists should be aware of the limitations and pitfalls of screening and risks such as overdiagnosis and should include those considerations in stories about screening tests.

Fawning Coverage of New Technologies
Journalists often do not question the proliferation of expensive technologies.

I would add that journalists rarely question the value or evidence for alternative therapies and tend to fawn over them and their proponents more often than not. Reporting that is truly informative and useful must be thoughtful and based on assessment of the real evidence, not simply unquestioningly enthusiastic about therapies with a token quote or two from skeptics for “balance.” Drugs are not the only medical treatment to have risks, but it seems journalists are far more likely to talk about the risks of pharmaceuticals than other treatments.

Uncritical Health Business Stories
Health business stories often provide cheerleading for local researchers and businesses, not a balanced presentation of what new information means for patients. Journalists should be more skeptical of what they are told by representatives of the health care industry.

I would argue that identifying any potential bas, financial or otherwise, in a source for a news story should be an ordinary part of journalistic practice. The idea behind seeking multiple sources is not just to provide a superficial impression of balance by including opposing points of view regardless of merit but to ensure that the journalist has a comprehensive awareness of the evidence for and against the treatment they are writing about so that they can provide a useful explanation of what is known about it. The study also found, however, that journalists often don’t follow this practice.

Single-Source Stories and Journalism Through News Releases
Half of all stories reviewed relied on a single source or failed to disclose the conflicts of interest of sources. However, journalists are expected to independently vet claims. Our project identified 121 stories (8% of all applicable stories) that apparently relied solely or largely on news releases as the source of information.

There really shouldn’t be any need to point out that this is lazy and unacceptable journalistic practice and does not lead to accurate, useful information for the public.

I don’t want to suggest that there are not many excellent journalists providing accurate and informative interpretation and analysis of healthcare research. The study specifically identifies examples of stories that succeeded in avoiding the mistakes they found, and there are certainly many in the media who do a brilliant job reporting and explaining health sciences research. Hopefully, by identifying common problems and mistakes, this study will contribute to improving the quality of healthcare science journalism.

Posted in General | 1 Comment